CONTRIBUTION OF DIFFERENT TYPES OF MELATONINE RECEPTORS TO HORMONE-DEPENDENT REGULATION OF T LYMPHOCYTES PRODUCING IL-17 (TH17) DIFFERENTIATION
- 作者: Glebezdina N.1, Nekrasova I.1, Olina A.2, Sadykova G.3
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隶属关系:
- IEGM UB RAS
- D.О. Ott Research Institute of Obstetrics, Gynecology and Reproductology
- Perm State Medical University named after E. A. Wagner of the Ministry of Healthcare of the Russian Federation
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 751-753
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119489
- DOI: https://doi.org/10.31857/S102872210006713-9
- ID: 119489
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全文:
详细
The involvement of different types of melatonin receptors in hormone-dependent regulation of the differentiation of T helpers producing IL-17 (Th17) was studied. It has been shown that in low physiological concentrations melatonin realized effects through membrane receptors, whereas the action of the hormone’s pharmacological concentrations was mediated by both membrane and nuclear receptors and was dose dependent.
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作者简介
N. Glebezdina
IEGM UB RAS
编辑信件的主要联系方式.
Email: glebezdina_n@mail.ru
PhD, Junior Researcher, Laboratory of Immunoregulation,
Perm
俄罗斯联邦I. Nekrasova
IEGM UB RAS
Email: fake@neicon.ru
PhD, Researcher, Laboratory of Immunoregulation,
Perm
俄罗斯联邦A. Olina
D.О. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: fake@neicon.ru
DMedSc, Deputy Director for Development,
Perm
俄罗斯联邦G. Sadykova
Perm State Medical University named after E. A. Wagner of the Ministry of Healthcare of the Russian Federation
Email: fake@neicon.ru
PhD, Assistant Professor of the Department of Obstetrics and Gynecology,
Perm
俄罗斯联邦参考
- Mahmood D. Pleiotropic Effects of Melatonin. Drug Res (Stuttg). 2019, 69(02), 65–74.
- Куклина Е. М., Глебездина Н. С., Некрасова И. В. Роль мелатонина в контроле дифференцировки Т-лимфоцитов, продуцирующих интерлейкин-17 (Th17). Бюллетень экспериментальной биологии и медицины. 2015. 160; 11, 604–607.
- Jadidi-Niaragh F., Mirshafiey A. Th17 cell, the new player of neuroinflammatory process in multiple sclerosis. Scand J Immunol. 2011. 74(1), 1–13.
- Slominski R. M., Reiter R. J., Schlabritz-Loutsevitch N., Ostrom R. S., Slominski A. T. Melatonin membrane receptors in peripheral tissues: distribution and functions. Molecular and Cellular Endocrinology. 2012. 351(2), 152–166.
- Gooneratne N. S., Edwards A. Y., Zhou C., Cuellar N., Grandner M. A., Barrett J. S. Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adults. J. Pineal Res. 2012. 52, 4, 437–445.
