CHARACTERISTICS OF REMODELLING REGULATORY IMMUNE MECHANISMS IN CARTILAGE AND BONE TISSUES AT INCIPIENT AND LATE PRESENTATIONS OF PRIMARY AND POST-TRAUMATIC OSTEOARTHROSIS

The interrelations of lymphocyte subpopulations pattern in peripheral blood and level of cartilage (Urine CartiLaps (CTX II) and bone (Serum CrossLaps) tissue metabolic markers in biological media exemplifi ed by 74 patients with incipient (0‒I) and late (III‒IV) stages of primary and post-traumatic osteoarthrosis as well as 20 healthy persons aged 45.9±11.4 have been studied. The activation of bone tissue destruction and cartilage extra-cellular matrix disorganization has been discovered at 0-I stages of primary OA, III‒IV stages of primary and post-traumatic osteoarthrosis. The evidences of immunodepression for T-cell immunity have been revealed represented by decrease of (CD3⁺CD4⁺) and (CD3⁺CD8⁺) lymphocytes. The presence (р<0.05) of mean strength (R = –0.66) negative interrelations between (CD3⁺CD4⁺) lymphocytes and Urine CartiLaps as well as (R = –0.70) between (CD3⁺CD8⁺) cells and (Serum CrossLaps) at late stages of primary and post-traumatic osteoarthrosis has been proven. In virtue of the obtained results the conclusion about incipient stages of primary osteoarthrosis being characterized with more signifi cant processes of cartilage extra-cellular matrix disorganization and bone tissue destruction has been drawn. III‒IV stages of both primary and post-traumatic osteoarthrosis are characterized with profound loss of type I and II collagen and accumulation of their degradation impurities in biological media accompanied by evidences of cell-immunity depression represented by decrease of T-lymphocytes count due to (CD3⁺CD4⁺) and (CD3⁺CD8⁺) pools. This proves the generality of pathogenetic remodelling regulatory mechanisms in bone and cartilage skeletal tissues at late presentations of the disease.

osteoarthrosis, cellular immunity, cartilage and bone tissue remodeling