β-ENDORPHIN REGULATION OF SECRETORY ACTIVITY OF PERITONEAL CAVITY CELLS IN MICE UNDER STRESS CONDITION

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It was found that the 2-h immobilization stress reduced the secretion of reactive oxygen species (ROS) and IL-1β by cells of the peritoneal cavity of mice. The introduction to mice of β-endorphin at doses of 100 and 0.0005 μg / kg before immobilization modulated the eff ects of stress.

作者简介

S. Gein

Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences;
Perm State Research University

编辑信件的主要联系方式.
Email: gein@iegm.ru

doctor of medicine, deputy director for research Institute of Ecology and Genetics of Microorganisms;

professor, Department of microbiology and immunology,

Perm

俄罗斯联邦

参考

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  3. Гейн С. В., Баева Т. А., Небогатиков В. О. // Доклады Академии наук. 2016. 469(6).749–752.
  4. O`Connor T. M., O`Halloran D. J., Shanahan F. The stress response and the hypotalamic- pituitary- adrenal axis: from molecule to melancholia. Oxford J. Medicine. 2000. 93. 323–333.
  5. Bilkei-Gorzo A., Racz I., Michel K., Mauer D., Zimmer A., Klingmüller D., Zimmer A. Control of hormonal stress reactivity by the endogenous opioid system. Psychoneuroendocrinology. 2008. 33. 425–436.

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