HUMORAL AND CELLULAR IMMUNITY IN HUMANS VACCINATED AND REVACCINATED AGAINST MENINGOCOCCAL INFECTION

M. S. Blyakher; Бляхер М. С.; I. M. Fedorova; Федорова И. М.; S. I. Koteleva; Котелева С. И.; Z. K. Ramazanova; Рамазанова З. К.; S. Yu. Kombarova; Комбарова С. Ю.; I. G. Martynenko; Мартыненко И. Г.; E. A. Tulskaya; Тульская Е. А.

doi:10.31857/S102872210007047-6

HUMORAL AND CELLULAR IMMUNITY IN HUMANS VACCINATED AND REVACCINATED AGAINST MENINGOCOCCAL INFECTION

作者: Blyakher M.¹, Fedorova I.², Koteleva S.², Ramazanova Z.², Kombarova S.², Martynenko I.², Tulskaya E.²
隶属关系:
1. G. N. Gabrichevsky Research Institute of epidemiology and microbiology Moscow
2. G. N. Gabrichevsky Research Institute of epidemiology and microbiology
期: 卷 22, 编号 4 (2019)
页面: 1429-1431
栏目: ORIGINAL ARTICLES
URL: https://journals.rcsi.science/1028-7221/article/view/119463
DOI: https://doi.org/10.31857/S102872210007047-6
ID: 119463

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详细

T-lymphocytes of vaccinated peopleare involved in the post-vaccination immune response to the polysaccharide vaccine against the A, C, Y and W serogroups of N. meningitidis even if the vaccine is not a glycoprotein conjugate, but the functional activity of T-lymphocytes producing IFNγ and IL-4 is diff erent in the primary and secondary response to the vaccine.If in revaccinated people the humoral immune response to the A-polysaccharide of N. meningitidis is poorly developed, there is the lack of activity of T-lymphocytes that produce IFNγ in their blood and the change in the balance between the activity of Th1 and Th2 is more similar to the dynamics of the primary vaccinated people, rather than successfully revaccinated.

关键词

T-lymphocytes, IFNγ, IL-4, antibodies against N.meningitides

作者简介

M. Blyakher

G. N. Gabrichevsky Research Institute of epidemiology and microbiology
Moscow

Email: fake@neicon.ru

DSci (Medicine), Professor, Head of the Laboratory for the Study of Cellular and Molecular Bases of Immunity,

Moscow

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