INVESTIGATION OF NEUTROPHIL MIGRATION VIA LYMPHATIC VESSELS IN THE COURSE OF A. FUMIGATUS-INDUCED INFLAMMATION

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Neutrophils are the main eff ector cells that are mediated immune response to exogenous pathogens including opportunistic fungi Aspergillus fumigatus. Neutrophils infi ltrate infl amed tissues and massively die during the fi ght against pathogen. However, in some cases neutrophils survive and migrate to lymphatic vessels to neutralize residual pathogens and activate adaptive immune response. In the present study we characterized the ability of neutrophils to migrate via lymphatic vessels during A. fumigatus conidia-induced infl ammation. As a result, new data about neutrophils migration kinetics to lymphatic vessels and the role of neutrophils in control of fungal spore dissemination in the host organism were obtained.

作者简介

E. Bolkhovitina

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

编辑信件的主要联系方式.
Email: alenkash83@gmail.com

JRF Laboratory of Cell Interactions,

Moscow

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A. Fedorina

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS;
Moscow Institute of Physics and Technology

Email: fake@neicon.ru

Student, Moscow;

Dolgoprugniy

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A. Bogorodskiy

Lomonosov Moscow State University

Email: fake@neicon.ru

PhD student,

Moscow

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A. Smirnova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS;
Lomonosov Moscow State University

Email: fake@neicon.ru

Student,

Moscow

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E. Chursanova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS;
Moscow Institute of Physics and Technology

Email: fake@neicon.ru

Student, Moscow;

Dolgoprugniy

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A. Sapozhnikov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: fake@neicon.ru

Professor, Head of the Laboratory of Cell Interactions, 

Moscow

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V. Borshchevskiy

Lomonosov Moscow State University

Email: fake@neicon.ru

PhD, SRF, Laboratory for Advanced Studies of Membrane Proteins,

Moscow

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M. Shevchenko

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: fake@neicon.ru

PhD, RF, Laboratory of Cell Interactions,

Moscow

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参考

  1. Bogoslowski A., Butcher E. C., Kubes P. Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminating Staphylococcus aureus. Proc Natl Acad Sci USA. 2018;115(10):2449–2454.
  2. Lu T., Kobayashi S. D., Quinn M. T., Deleo F. R. A NET Outcome. Front Immunol. 2012 Dec 5;3:365.
  3. Abadie V., Badell E., Douillard P., Ensergueix D., Leenen P. J., Tanguy M., Fiette L., Saeland S., Gicquel B., Winter N. Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes. Blood. 2005 Sep 1;106(5):1843–50.
  4. Shevchenko M.A., Bogorodskiy A.O., Troyanova N.I., Servuli E. A., Bolkhovitina E. L., Büldt G., Fahlke C., Gordeliy V. I., Gensch T., Borshchevskiy V. I., Sapozhnikov A. M. Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice. J Immunol Res. 2018 Jan 18; 2018:5379085.

版权所有 © Bolkhovitina E.L., Fedorina A.S., Bogorodskiy A.O., Smirnova A.O., Chursanova E.N., Sapozhnikov A.M., Borshchevskiy V.I., Shevchenko M.A., 2019

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