IMMUNOLOGICAL CORRELATES OF A CANDIDATE DNA VACCINE AGAINST HIV-1 SUBTYPE A
- 作者: Akulova E.1, Murashev B.2, Nazarenko O.2, Verevochkin S.1, Masharsky A.1, Al Shekhadat R.1, Lioznov D.3, Kozlov A.1,2
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隶属关系:
- State Research Institute of Highly Pure Biopreparations
- The Biomedical Center
- Pavlov First Saint Petersburg State Medical University
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 136-138
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119359
- DOI: https://doi.org/10.31857/S102872210006427-4
- ID: 119359
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全文:
详细
Since 1981, when AIDS was identified as a disease about 60 million of HIV infected people have been registered and 30 million have died according to WHO. The development of vaccines against HIV/AIDS is an important step in solving this problem. In the absence of an adequate animal model for HIV, vaccine development requires an understanding of immunological correlates of HIV protection. In this study we investigated the immunological correlates of a candidate HIV-1 DNA vaccine. We analyzed the specific immune responses in phase I clinical trial participants and in HIV exposed seronegative individuals. In both groups, an increase in TNFα cytokine by CD4+ T cells in response to specific peptide stimulation was found. This could be an indicator of the possible vaccine efficacy.
作者简介
E. Akulova
State Research Institute of Highly Pure Biopreparations
编辑信件的主要联系方式.
Email: e.b.akulova@hpb.spb.ru
Deputy Head of Laboratory of HIV Molecular Biology,
St. Petersburg
俄罗斯联邦B. Murashev
The Biomedical Center
Email: fake@neicon.ru
PhD, Senior Researcher,
St. Petersburg
俄罗斯联邦O. Nazarenko
The Biomedical Center
Email: fake@neicon.ru
Researcher,
St. Petersburg
俄罗斯联邦S. Verevochkin
State Research Institute of Highly Pure Biopreparations
Email: fake@neicon.ru
Senior Researcher of Laboratory of HIV Molecular Biology,
St. Petersburg
俄罗斯联邦A. Masharsky
State Research Institute of Highly Pure Biopreparations
Email: fake@neicon.ru
PhD, Leading Researcher of Laboratory of HIV Molecular Biology,
St. Petersburg
俄罗斯联邦R. Al Shekhadat
State Research Institute of Highly Pure Biopreparations
Email: fake@neicon.ru
PhD, Leading Researcher of Laboratory of HIV Molecular Biology,
St. Petersburg
俄罗斯联邦D. Lioznov
Pavlov First Saint Petersburg State Medical University
Email: fake@neicon.ru
MD, Head of Dept. of Infectious Diseases and Epidemiology,
St. Petersburg
俄罗斯联邦A. Kozlov
State Research Institute of Highly Pure Biopreparations;The Biomedical Center
Email: fake@neicon.ru
D. Sc., Prof., Head of Laboratory of HIV Molecular Biology;
Director,
St. Petersburg
俄罗斯联邦参考
- Murashev B. V., Nazarenko O. V., Akulova E. B., Artemyeva A. K., Verevochkin S. V., Shaboltas A. V., Skochilov R. V., Toussova O. V., Kozlov A. P. The high frequency of HIV type 1-specific cellular immune responses in seronegative individuals with parenteral and/or heterosexual HIV type 1 exposure. AIDS Res Hum Retroviruses. 2012, 12, 1598–605.
- Akulova E., Murashev B., Nazarenko O., Verevochkin S., Masharsky A., Krasnoselskikh T., Lioznov D., Sokolovsky E., Kozlov A. P. Immune Responses Induced by Candidate Optimized HIV DNA Vaccine in Phase I Clinical Trial. Madridge J Vacc. 2017, 1(1), 34–43.
