INFLUENCE OF METHYLPREDNISOLON ON THE ACTIVATION OF TCR-STIMULATED CD4+CD45RO+ T-LYMPHOCYTES IN PATIENTS WITH RHEUMATOID ARTHRITIS IN THE SYSTEM IN VITRO
- Authors: Todosenko N.M.1, Yurov C.A.1, Haziahmatova O.G.1, Litvinova L.S.1
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Affiliations:
- Baltic Federal University. Kant
- Issue: Vol 20, No 3 (2017)
- Pages: 534-536
- Section: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/119953
- ID: 119953
Cite item
Abstract
The effect of methylprednisolone (MP) on the functional activity of CD4+ CD45RO+ T cells obtained in patients with rheumatoid arthritis (RA) and healthy donors in the in vitro system was studied. It has been shown that MP significantly reduces the number of TCR-activated СD4+СD45RO+СD25+ and СD4+СD45RO+СD71+ T-lymphocytes in cultures of RA patients and in healthy donors. MP, reducing the number of СD4+СD28+ T cells, promotes the formation of terminal-differentiated memory effector T-cells.
Keywords
About the authors
N. M. Todosenko
Baltic Federal University. Kant
Author for correspondence.
Russian Federation
C. A. Yurov
Baltic Federal University. KantRussian Federation
O. G. Haziahmatova
Baltic Federal University. KantRussian Federation
L. S. Litvinova
Baltic Federal University. KantRussian Federation
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