RELATIONSHIP SERUM LEVELS AND GENE POLYMORPHISMS OF IL-1a, IL-1RA WITH EFFICIENCY OF IN VITRO FERTILIZATION (IVF)
- Authors: Lapshtaeva A.V.1, Radaeva O.A.1, Novicova L.V.1, Efremov I.A.2
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Affiliations:
- Ogarev Mordovia State University
- Institute of biochemical physics of N. M. Emanuel Russian Academy of Sciences
- Issue: Vol 20, No 3 (2017)
- Pages: 402-404
- Section: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/119589
- ID: 119589
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Abstract
Women with tubal peritoneal infertility with an effective IVF had concentrations of IL-1a, IL-1ra in serum lower that women ineffective IVF. Genotype T/T gene IL-1a rs1800587 5'UTR area of the gene is associated with approach of pregnancy as a result of IVF (OR = 85,3, 95 %CI: 10,6-687, p<0,05).
About the authors
A. V. Lapshtaeva
Ogarev Mordovia State University
Author for correspondence.
Russian Federation
O. A. Radaeva
Ogarev Mordovia State UniversityRussian Federation
L. V. Novicova
Ogarev Mordovia State UniversityRussian Federation
I. A. Efremov
Institute of biochemical physics of N. M. Emanuel Russian Academy of SciencesRussian Federation
References
- Putowski L., Darmohwal-Kolaz D., Oleszczuk J. The immunological profile of infertility women with after repeated IVF failures (preliminary study). Eur. J. Obstet. Gynecol. Reprod. Biol. 2004, 112(2), 192-196.
- Мотовилова Н. О., Коган И. Ю., Сысоев К. А., Буйнова А. Н., Грязнов А. Ю. и др. Роль некоторых цитокинов в эффективности лечения бесплодия методом экстракорпорального оплодотворения. Медицинская иммунология 2012, 14(4-5), 373-382.
- Di Paolo N. C., Shayakhmetov D. M. Interleukin 1α and the inflammatory process. Nature Immunology 2016, 17(8), 906-913.
- Алиева К. У, Кузьмичев Л. Н., Смольникова В. Ю., Ипатова М. В., Комиссарова Ю. В. Новые возможности подготовки эндометрия в программах вспомогательных репродуктивных технологий. Вестник новых медицинских технологий 2007, XIV(3), 6-8.
- Goto H., Ishihara Y., Kikuchi T., Izawa A., Ozeki N., et al. Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression. PLos One. 2015, 10(10), e0140942. doi: 10.1371/journal.pone.0140942
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