Immunotherapy is a new opportunity for managing patients with “thin” endometrium in cycles of transfer of thawed embryos
- Authors: Lysenko O.V.1,2, Bresski A.G.1, Ogryzko I.N.1
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Affiliations:
- Vitebsk State Medical University
- BINA Family Health Center
- Issue: Vol 27, No 2 (2024)
- Pages: 293-298
- Section: SHORT COMMUNICATIONS
- URL: https://journals.rcsi.science/1028-7221/article/view/263690
- DOI: https://doi.org/10.46235/1028-7221-16646-IIA
- ID: 263690
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Abstract
The trend of recent decades has been the search for therapeutic effects on the so-called “thin” endometrium. However, to date there is no optimal management scheme for patients with “thin” endometrium in assisted reproductive technology programs. Aim: to evaluate the effectiveness of using recombinant IL-2 before cryotransfer in women of late reproductive age with “thin” endometrium and repeated implantation failure after transfer of good quality embryos.
The study included 63 patients of late reproductive age with “thin” endometrium. The first group consisted of 25 patients of late reproductive age with a history of unsuccessful in vitro fertilization programs with good quality embryos. Cryotransfer to the patients of the first group was carried out in a modified natural cycle. The second group included 38 women of late reproductive age with a history of unsuccessful in vitro fertilization programs with good quality embryos. Cryotransfer for women of the second group was carried out in a cycle with hormone replacement therapy. Recombinant IL-2 in the cycle before cryotransfer were prescribed to all women. In both groups, implantation, clinical pregnancy, and live birth rates following administration of recombinant IL-2 were valuable. In both groups, the implantation rate, clinical pregnancy rate and live birth rate were assessed after administration of recombinant IL-2. Statistical data processing was performed using application software package Statistica 6.0 (StatSoft, Ink. 1994-2001), adapted for biomedical research. p < 0.05 was considered significant.
After recombinant IL-2 treatment of patients with infertility and thin endometrium, endometrial thickness increases statistically significantly in the first two menstrual cycles after treatment, so transfer of thawed embryos should be planned in the first two menstrual cycles after immunotherapy.
In order to increase the thickness of the endometrium during cryotransfer in a modified natural cycle, as well as in a cycle with replacement hormone therapy, recombinant IL-2 can be used in women with “thin” endometrium with repeated unsuccessful implantation attempts when transferring good quality embryos.
Cryotransfer should be performed in the first two menstrual cycles after immunotherapy.
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##article.viewOnOriginalSite##About the authors
O. V. Lysenko
Vitebsk State Medical University; BINA Family Health Center
Author for correspondence.
Email: lysenko_o_v@mail.ru
PhD, MD (Medicine), Professor, Department of Obstetrics and Gynecology; Obstetrician-Gynecologist, Reproductologist
Belarus, Vitebsk; VitebskA. G. Bresski
Vitebsk State Medical University
Email: lysenko_o_v@mail.ru
PhD (Medicine), Associate Professor, Department of Obstetrics and Gynecology
Belarus, VitebskI. N. Ogryzko
Vitebsk State Medical University
Email: lysenko_o_v@mail.ru
PhD (Medicine), Associate Professor, Department of Obstetrics and Gynecology
Belarus, VitebskReferences
- Лысенко О.В., Рождественская Т.А. Проблема «тонкого» эндометрия в репродуктивной медицине: опыт применения рекомбинантного интерлейкина-2 человека для подготовки пациенток к программам вспомогательных репродуктивных технологий // Журнал акушерства и женских болезней, 2017, Т. 66, № 4. C. 46-50. [Lysenko O.V., Rozhdestvenskaya T.A. The problem of “thin” endometrium in reproductive medicine: experience of using recombinant human interleukin-2 to prepare patients for assisted reproductive technology programs. Zhurnal akusherstva i zhenskikh bolezney = Journal of Obstetrics and Women’s Diseases, 2017, Vol. 66, no. 4, pp. 46-50. (In Russ.)]
- Capalbo A., Romanelli V., Cimadomo D., Girardi L., Stoppa M., Dovere L., Dell’Edera D., Ubaldi F.M., Rienzi L.J. Implementing PGD/PGD-A in IVF clinics: considerations for the best laboratory approach and management. Assist. Reprod. Genet., 2016, Vol. 33, no. 10, pp. 1279-1286.
- De la Torre Perez E., Carratalá-Munuera M.C., Castillo-Farfán J.C., Lledó-Bosch B., Moliner-Renau B., Bernabeu-García A., Bernabeu-Pérez R. Impact of endometrial compaction on reproductive outcomes after cryotransfer of euploid embryos in a modified natural cycle: protocol for a prospective cohort study. Front. Endocrinol. (Lausanne), 2023, no. 14, 1285040. doi: 10.3389/fendo.2023.1285040.
- Kushnir V.A., Solouki S., Sarig-Meth T., Vega M.G., Albertini D.F., Darmon S.K., Deligdisch L., Barad D.H., Gleicher N. Systemic inflammation and autoimmunity in women with chronic endometritis. Am. J. Reprod. Immunol., 2016, Vol. 75, no. 6, pp. 672-327.
- Lebovitz O., Orvieto R. Treating patients with “thin” endometrium – an ongoing challenge. Gynecol. Endocrinol., 2014, Vol. 30, no. 6, pp. 409-414.
- Ma J., Gao W., Li D. Recurrent implantation failure: A comprehensive summary from etiology to treatment. Front. Endocrinol. (Lausanne), 2023, no. 13, 1061766. doi: 10.3389/fendo.2022.1061766.
- McLernon D.J., Harrild K., Bergh C., Davies M.J., de Neubourg D., Dumoulin J.C., Gerris J., Kremer J.A., Martikainen H., Mol B.W., Norman R.J., Thurin-Kjellberg A., Tiitinen A., van Montfoort A.P., van Peperstraten A.M., van Royen E., Bhattacharya S. Clinical effectiveness of elective single versus double embryo transfer: meta-analysis of individual patient data from randomised trials. BMJ, 2010, no. 341, 6945. doi: 10.1136/bmj.c6945.
- McQueen D.B., Bernardi L.A., Stephenson M.D. Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise. Fertil. Steril., 2014, Vol. 101, no. 4, pp. 1026-1030.
- Singh B., Reschke L., Segars J., Baker V.L. Frozen-thawed embryo transfer: the potential importance of the corpus luteum in preventing obstetrical complications. Fertil. Steril., 2020, Vol. 113, no. 2, pp. 252-257.
- Viotti M., Victor A.R., Barnes F.L., Zouves C.G., Besser A.G., Grifo J.A., Cheng E.H., Lee M.S., Horcajadas J.A., Corti L., Fiorentino F., Spinella F., Minasi M.G., Greco E., Munné S. Using outcome data from one thousand mosaic embryo transfers to formulate an embryo ranking system for clinical use. Fertil Steril., 2021, Vol. 115, no. 5, pp. 1212-1224.
- Vitagliano A., Paffoni A., Viganò P. Does maternal age affect assisted reproduction technology success rates after euploid embryo transfer? A systematic review and meta-analysis. Fertil. Steril., 2023, Vol. 120, no. 2, pp. 251-265.
