Soluble receptor for advanced glycation endproducts (sRAGE) as a new biomarker of asthma in children: a brief review of the literature and our own findings
- 作者: Tereshchenko S.Y.1, Smolnikova M.V.1, Gorbacheva N.N.1
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隶属关系:
- Research Institute of Medical Problems of the North, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences
- 期: 卷 27, 编号 2 (2024)
- 页面: 237-242
- 栏目: SHORT COMMUNICATIONS
- URL: https://journals.rcsi.science/1028-7221/article/view/263682
- DOI: https://doi.org/10.46235/1028-7221-16663-SRF
- ID: 263682
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In recent years, the receptor of glycosylation end products (RAGE) has increasingly attracted the attention of researchers and plays an important role in various in various diseases associated with tissue destruction, metabolic and neurodegenerative processes, infections, immune reactions and inflammation of various origins. The study of the soluble form of this receptor (sRAGE) as a potential biomarker for the diagnosis and monitoring of bronchial asthma (BA) in children is becoming particularly relevant.
This article presents a brief review of the literature on the role of RAGE and its ligands in the pathogenesis of respiratory diseases, and analyzes our own data on the study of sRAGE levels in children with AD.
We examined 101 children aged 7-18 years suffering from AD referred to the Children’s Allergy Center (Krasnoyarsk, Russia). Children with AD were divided into three groups: controlled (n = 45), partially controlled (n = 19) and uncontrolled asthma (n = 37) according to GINA-2023. The control group consisted of 92 age- and sex-matched children (virtually healthy children without signs of infection or allergy). Serum sRAGE levels were determined by magnetic immunoassay (MAGPIX, Luminex, USA; Merk Millipore, USA). Data are presented as median (25-75% quartiles). The Kruskal–Wallis test was used.
Serum sRAGE levels were reduced only in uncontrolled AD in the examined children (Figure 1, p (Kruskal–Wallis test) = 0.001). In addition, serum sRAGE levels were reduced in the asthma exacerbation groups, regardless of exacerbation status caused by viral infection or allergens.
Thus, serum sRAGE levels are closely related to asthma control and exacerbation status in children with AD in and may be used as a novel marker of loss of disease control and possibly as a potential target for therapeutic intervention.
作者简介
S. Tereshchenko
Research Institute of Medical Problems of the North, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences
Email: legise@mail.ru
PhD, MD (Medicine), Professor, Head, Clinical Department of Somatic and Mental Health of Children
俄罗斯联邦, KrasnoyarskM. Smolnikova
Research Institute of Medical Problems of the North, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: legise@mail.ru
PhD (Biology), Head, Molecular Genetic Research Group, Leading Research Associate
俄罗斯联邦, KrasnoyarskN. Gorbacheva
Research Institute of Medical Problems of the North, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences
Email: legise@mail.ru
Senior Research Associate
俄罗斯联邦, Krasnoyarsk参考
- Терещенко С., Смольникова М. Врожденные дисфункции паттерн-распознающих рецепторов в патогенезе инвазивной и рецидивирующей пневмококковой инфекции у детей // Инфекция и иммунитет, 2019. T. 9, № 2. С. 229-238. [Congenital dysfunctions of pattern-recognizing receptors in the pathogenesis of invasive and recurrent pneumococcal infection in children. Infektsiya i immunitet = Russian Journal of Infection and Immunity, 2019, Vol. 9, no. 2, pp. 229-238. (In Russ.)] doi: 10.15789/2220-7619-2019-2-229-238.
- Birben E., Şahiner Ü.M., Kalaycı C. Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. Turk. J. Med. Sci., 2023, Vol. 53, no. 1, pp. 160-170.
- Delrue C., Delanghe J.R., Speeckaert M.M. The role of sRAGE in cardiovascular diseases. Adv. Clin. Chem., 2023, Vol. 117, pp. 53-102.
- Hancock D.B., Eijgelsheim M., Wilk J.B., Gharib S.A., Loehr L.R., Marciante K.D., Franceschini N., van Durme Y.M.T.A., Chen T.-H., Barr R.G., Schabath M.B., Couper D.J., Brusselle G.G., Psaty B.M., van Duijn C.M., Rotter J.I., Uitterlinden A.G., Hofman A., Punjabi N.M., Rivadeneira F., Morrison A.C., Enright P.L., North K.E., Heckbert S.R., Lumley T., Stricker B.H.C., O'Connor G.T., London S.J. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat. Genet., 2010, Vol. 42, no. 1, pp. 45-52.
- Hu H., Hu X., Wang Z., Gao L., Jin J., Xia J., Huang L., Li S. Clinical value of serum soluble receptor for advanced glycation end products in evaluating the condition of patients with bronchial asthma. Allergy Asthma Proc., 2023, Vol. 44, no. 4, pp. 258-264.
- Kerkhof M., Boezen H.M., Granell R., Wijga A.H., Brunekreef B., Smit H.A., de Jongste J.C., Thijs C., Mommers M., Penders J., Henderson J., Koppelman G.H., Postma D.S. Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes. J. Allergy Clin. Immunol., 2014, Vol. 133, no. 1, pp. 68-76.e61-64.
- Li Y., Wu R., Tian Y., Bao T., Tian Z. Fraction of exhaled nitric oxide and soluble receptors for advanced glycation end products are negatively correlated in children with recurrent wheezing. Asian Pac. J. Allergy Immunol., 2017, Vol. 35, no. 1, pp. 33-37.
- Moser B., Desai D.D., Downie M.P., Chen Y., Yan Sh.F., Herold K., Schmidt A.M., Clynes R. Receptor for advanced glycation end products expression on T cells contributes to antigen-specific cellular expansion in vivo. J. Immunol., 2007, Vol. 179, no. 12, pp. 8051-8058.
- Raita Y., Zhu Z., Freishtat R.J., Fujiogi M., Liang L., Patregnani J.T., Camargo C.A., Hasegawa K. Soluble receptor for advanced glycation end products (sRAGE) and asthma: Mendelian randomisation study. Pediatr. Allergy Immunol., 2021, Vol. 32, no. 5, pp. 1100-1103.
- Repapi E., Sayers I., Wain L.V., Burton P.R., Johnson T., Obeidat M., Zhao J.H., Ramasamy A., Zhai G., Vitart V., Huffman J.E., Igl W., Albrecht E., Deloukas P., Henderson J., Granell R., McArdle W.L., Rudnicka A.R.; Wellcome Trust Case Control Consortium; Barroso I., Loos R.J.F., Wareham N.J., Mustelin L., Rantanen T., Surakka I., Imboden M., Wichmann H.E., Grkovic I., Jankovic S., Zgaga L., Hartikainen A.-L., Peltonen L., Gyllensten U., Johansson A., Zaboli G., Campbell H., Wild S.H., Wilson J.F., Gläser S., Homuth G., Völzke H., Mangino M., Soranzo N., Spector T.D., Polasek O., Rudan I., Wright A.F., Heliövaara M., Ripatti S., Pouta A., Naluai A.T., Olin A.C., Torén K., Cooper M.N., James A.L., Palmer L.J., Hingorani A.D., Wannamethee S.G., Whincup P.H., Smith G.D., Ebrahim S., McKeever T.M., Pavord I.D., MacLeod A.K., Morris A.D., Porteous D.J., Cooper C., Dennison E., Shaheen S., Karrasch S., Schnabel E., Schulz H., Grallert H., Bouatia-Naji N., Delplanque J., Froguel P., Blakey J.D.; NSHD Respiratory Study Team; Britton J.R., Morris R.W., Holloway J.W., Lawlor D.A., Hui J., Nyberg F., Jarvelin M.-R., Jackson C., Kähönen M., Kaprio J., Probst-Hensch N.M., Koch B., Hayward C., Evans D.M., Elliott P., Strachan D.P., Hall I.P., Tobin M.D. Genome-wide association study identifies five loci associated with lung function. Nat. Genet., 2010, Vol. 42, no. 1, pp. 36-44.
- Sierra-Colomina M., García-Salido A., Leoz-Gordillo I., de Azagra-Garde A.M., Melen G., García-Teresa M.Á., Iglesias-Bouzas M., Nieto-Moro M., Ramírez-Orellana M., Serrano-González A. sRAGE as severe acute bronchiolitis biomarker, prospective observational study. Pediatr. Pulmonol., 2020, Vol. 55, no. 12, pp. 3429-3436.
- Sukkar M.B., Ullah M.A., Gan W.J., Wark P.A., Chung K.F., Hughes J.M., Armour C.L., Phipps S. RAGE: a new frontier in chronic airways disease. Br. J. Pharmacol., 2012, vol. 167, no. 6, pp. 1161-1176.
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