Markers of eosinophilic inflammation of airways in patients with fungal sensitilization
- 作者: Vasiliev N.Y.1, Kozlova Y.I.1, Frolova E.V.1, Uchevatkina A.E.1, Filippova L.V.1, Aak O.V.1, Sobolev A.V.1, Vasilieva N.V.1
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隶属关系:
- North-Western State I. Mechnikov Medical University
- 期: 卷 26, 编号 4 (2023)
- 页面: 547-552
- 栏目: Forum Sochi 2023
- URL: https://journals.rcsi.science/1028-7221/article/view/253440
- DOI: https://doi.org/10.46235/1028-7221-13616-MOE
- ID: 253440
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详细
Immunological characteristics of airway inflammation in asthma patients with sensitization to various fungal allergens are not well understood, and the search for new markers is necessary to establish future targets for targeted therapy. The purpose of our study was to assess the levels of eosinophilic inflammation markers of the respiratory tract in patients with severe asthma and allergic bronchopulmonary aspergillosis, depending on the spectrum of fungal sensitization.
The study included 31 patients with severe asthma with fungal sensitization and 29 patients with allergic bronchopulmonary aspergillosis (ABPA). The levels of total, specific IgE to fungal allergens and periostin in blood serum were determined by enzyme immunoassay. The study of basophil activation was performed by flow cytometry.
The patients with severe asthma and sensitization to Aspergillus spp. and Alternaria spp. had significantly higher levels of eosinophils, periostin, and stimulation index to Alternaria spp. in the basophil activation test when compared with the group of asthma patients with sensitization to Aspergillus spp. only. In patients with ABPA with combined sensitization, we have found significantly higher levels of eosinophils, periostin, and stimulation index to Alternaria spp.
The finding of pronounced eosinophilic type of inflammation in patients with asthma and combined sensitization to thermotolerant and thermolabile fungi may result from aggressive effect of fungal allergens on the barrier functions of bronchial epithelium, which should be taken into account when choosing therapeutic strategy and administration of immunobiological therapy.
作者简介
Nikolay Vasiliev
North-Western State I. Mechnikov Medical University
编辑信件的主要联系方式.
Email: wwjd2000@mail.ru
ORCID iD: 0000-0003-0793-2831
SPIN 代码: 2150-3380
Researcher ID: ABX-3797-2022
Postgraduate Student, Department of Clinical Mycology, Allergology and Immunology, North-Western State I. Mechnikov Medical University
俄罗斯联邦, St. PetersburgYa. Kozlova
North-Western State I. Mechnikov Medical University
Email: kozlova510@mail.ru
ORCID iD: 0000-0002-4602-2438
SPIN 代码: 5842-6039
PhD (Medicine), Associate Professor, Research Laboratory of Immunology and Allergology, North-Western State I. Mechnikov Medical University
俄罗斯联邦, St. PetersburgE. Frolova
North-Western State I. Mechnikov Medical University
Email: ekaterina.frolova@szgmu.ru
ORCID iD: 0000-0002-7696-2236
SPIN 代码: 9904-8776
PhD (Medicine), Head, Research Laboratory of Immunology and Allergology, North-Western State I. Mechnikov Medical University
俄罗斯联邦, St. PetersburgA. Uchevatkina
North-Western State I. Mechnikov Medical University
Email: a.uchevatkina@szgmu.ru
ORCID iD: 0000-0001-6688-7781
SPIN 代码: 3001-4022
PhD (Medicine), Senior Research Associate, Research Laboratory of Immunology and Allergology, North-Western State I. Mechnikov Medical University
俄罗斯联邦, St. PetersburgL. Filippova
North-Western State I. Mechnikov Medical University
Email: larisa.filippova@szgmu.ru
ORCID iD: 0000-0003-4167-7440
SPIN 代码: 6810-0871
PhD (Medicine), Senior Research Associate, Research Laboratory of Immunology and Allergology, North-Western State I. Mechnikov Medical University
俄罗斯联邦, St. PetersburgO. Aak
North-Western State I. Mechnikov Medical University
Email: wwjd2000@mail.ru
PhD (Chemistry), Leading Research Associate, Research Laboratory of Immunology and Allergology, North-Western State I. Mechnikov Medical University
俄罗斯联邦, St. PetersburgA. Sobolev
North-Western State I. Mechnikov Medical University
Email: sobolev757@rambler.ru
ORCID iD: 0000-0001-7866-1878
SPIN 代码: 5448-4106
PhD, MD (Medicine), Professor, Department of Clinical Mycology, Allergology and Immunology, North-Western State I. Mechnikov Medical University
俄罗斯联邦, St. PetersburgN. Vasilieva
North-Western State I. Mechnikov Medical University
Email: mycobiota@szgmu.ru
ORCID iD: 0000-0001-6095-7531
SPIN 代码: 9215-4069
PhD, MD (Biology), Professor, Director, P. Kashkin Research Institute of Medical Mycology, North-Western State I. Mechnikov Medical University
俄罗斯联邦, St. Petersburg参考
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