SECRETION OF TUMOR NECROSIS FACTOR ALPHA BY BLOOD EOSINOPHILS IN COLON CANCER WITH TISSUE EOSINOPHILIA
- Authors: Romanova E.V.1, Kolobovnikova Y.V.1, Urazova O.I.1,2, Novitskiy V.V.1,2
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Affiliations:
- Federal State Budgetary Institution of Higher Education «Siberian State Medical University» of the Ministry of Health of the Russian Federation
- Tomsk State University of Control Systems and Radioelectronics
- Issue: Vol 22, No 2-1 (2019)
- Pages: 496-498
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120280
- DOI: https://doi.org/10.31857/S102872210006943-2
- ID: 120280
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Abstract
We analyzed in vitro secretion of TNFα by peripheral blood eosinophil granulocytes in patients with colon cancer according to the presence of tumor-associated tissue eosinophilia. In colon cancer with tissue eosinophilia, an increase in basal and r-IL-5-induced in vitro secretion of TNFα by blood eosinophils was detected. It was shown that in patients with colon cancer, regardless of the presence of tissue eosinophilia, the levels of basal and r-IL-5-induced secretion of TNFα by eosinophil granulocytes in vitro were comparable.
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About the authors
E. V. Romanova
Federal State Budgetary Institution of Higher Education «Siberian State Medical University» of the Ministry of Health of the Russian Federation
Author for correspondence.
Senior Lecturer of the Microbiology and Virology Division,
Tomsk
Russian FederationYu. V. Kolobovnikova
Federal State Budgetary Institution of Higher Education «Siberian State Medical University» of the Ministry of Health of the Russian Federation
Email: kolobovnikova.julia@mail.ru
DMedSc, Professor of the Pathophysiology Division,
Tomsk
Russian FederationO. I. Urazova
Federal State Budgetary Institution of Higher Education «Siberian State Medical University» of the Ministry of Health of the Russian Federation;Tomsk State University of Control Systems and Radioelectronics
Email: kaf.pat.fiziolog@ssmu.ru
DMedSc, Professor, Corresponding Member of RAS, Head of the Pathophysiology Division;
Professor of the Department of Complex Information Security of Computer Systems,
Tomsk
Russian FederationV. V. Novitskiy
Federal State Budgetary Institution of Higher Education «Siberian State Medical University» of the Ministry of Health of the Russian Federation;Tomsk State University of Control Systems and Radioelectronics
DMedSc, Professor, Academician of RAS, Honored Scientist of Russia, Professor of the Pathophysiology Division;
Professor of the Department of Complex Information Security of Computer Systems,
Tomsk
Russian FederationReferences
- Varricchi G., Galdiero M. R., Loff redo S., Lucarini V., Marone G., Mattei F., Marone G., Schiavoni G. Eosinophils: The unsung heroes in cancer? Oncoimmunology. 2017, 7(2), e1393134.
- Legrand F., Driss V., Delbeke M., Loiseau S., Hermann E., Dombrowicz D., Capron M. Human eosinophils exert TNF-α and granzyme A-mediated tumoricidal activity toward colon carcinoma cells. J. Immunol. 2010, 185 (12), 7443–7451.
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