EFFECTS OF CARBOPLATIN WITH CUCURBIT[7]URIL ON SUBPOPULATION COMPOSITION AND PROLIFERATIVE ACTIVITY OF LYMPHOCYTES IN VITRO
- Authors: Pashkina E.A.1,2, Aktanova A.A.2, Ermakov A.A.2, Knauer N.Y.1, Mirzaeva I.V.3, Kovalenko E.A.3
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Affiliations:
- FSBSI “Research Institute of Fundamental and Clinical Immunology”
- Novosibirsk State Medical University
- Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 22, No 2-1 (2019)
- Pages: 462-464
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120261
- DOI: https://doi.org/10.31857/S102872210006930-8
- ID: 120261
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Abstract
It is known that the use of delivery systems can reduce the toxicity of platinum compounds without losing a high therapeutic effect. In this work, the immunotoxic effect of carboplatin when co-added with cucurbit[7]uril was investigated, including the effect on the subpopulation composition of lymphocytes and their proliferative activity in vitro.
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About the authors
E. A. Pashkina
FSBSI “Research Institute of Fundamental and Clinical Immunology”;Novosibirsk State Medical University
Author for correspondence.
Email: pashkina.e.a@yandex.ru
PhD, Researcher, Clinical Immunopathology Laboratory;
Assistant of the Department of Clinical Immunology at the Medical Faculty,
Novosibirsk
Russian FederationA. A. Aktanova
Novosibirsk State Medical University
six-year student of the Faculty of Medicine and Prevention of the specialty of Medical Biophysics,
Novosibirsk
Russian FederationA. A. Ermakov
Novosibirsk State Medical University
six-year student of the Faculty of Medicine and Prevention of the specialty of Medical Biophysics,
Novosibirsk
Russian FederationN. Yu. Knauer
FSBSI “Research Institute of Fundamental and Clinical Immunology”
PhD student, Clinical Immunopathology Laboratory,
Novosibirsk
Russian FederationI. V. Mirzaeva
Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences
PhD, Researcher, Laboratory of Condensed Matter Physical Chemistry,
Novosibirsk
Russian FederationE. A. Kovalenko
Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences
PhD, Researcher, Laboratory of cluster and supramolecular chemistry,
Novosibirsk
Russian FederationReferences
- Wheate N. J. Improving platinum (II)-based anticancer drug delivery using cucurbit [n] urils. Journal of inorganicbiochemistry. 2008, 102, 2060–2066.
- Mirzaeva I. V., Moroz N. K., Andrienko I. V., Kovalenko E. A. Interaction between carboplatin and cucurbit[7]uril studied by means of multinuclear NMR spectroscopy and DFT calculations J. Mol. Struct. 2018, 1163, 68–76.
- Актанова А. А., Ермаков А. А., Пашкина Е. А. Сравнительный анализ противоопухолевого и иммунотоксического действия комплекса кукурбит[7] урила с карбоплатином. Российский иммунологический журнал. 2018, 12(21), 595–597.
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