AUTOANTIBODIES TO THE MYELIN BASIC PROTEIN IN PATIENTS WITH SCHIZOPHRENIA HAVE PROTEOLYTIC ACTIVITY
- Authors: Parshukova D.A.1, Buneva V.N.2, Kornetova E.G.1, Kazantseva D.V.3, Vasilevа A.R.3, Ivanova S.A.1, Smirnova L.P.1
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Affiliations:
- Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
- Siberian Division of Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine
- Siberian State Medical University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 451-454
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120255
- DOI: https://doi.org/10.31857/S102872210006927-4
- ID: 120255
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Abstract
This work is devoted to the study of the association of MBP-hydrolyzing IgG activity with the level of antibodies to MBP in patients with schizophrenia. In the group of patients, a high level of specifi c proteolytic activity of antibodies (AT) and a twofold increase in the level of antibodies to MBP were found. A signifi cant positive correlation (r=0,48; p=0,026) was found between the studied parameters.
About the authors
D. A. Parshukova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
Author for correspondence.
Junior scientist of Molecular Genetics and Biochemistry Laboratory,
Tomsk
Russian FederationV. N. Buneva
Siberian Division of Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine
Ph D., Professor, Principal Researcher Laboratory of Reparation Enzymes,
Novosibirsk
Russian FederationE. G. Kornetova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
Ph D., Leading Researcher Departments of endogenous disorders,
Tomsk
Russian FederationD. V. Kazantseva
Siberian State Medical University
Student,
Tomsk
Russian FederationA. R. Vasilevа
Siberian State Medical University
Student,
Tomsk
Russian FederationS. A. Ivanova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
PhD, Professor, Deputy Director (Scientifi c Director) of Mental Health Research Institute,
Tomsk
Russian FederationL. P. Smirnova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
Email: lpsmirnova@yandex.ru
PhD, Senior Researcher of Molecular Genetics and Biochemistry Laboratory,
Tomsk
Russian FederationReferences
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