REGULATORY T-CELLS IN ACUTE ISCHEMIC STROKE AND THEIR RELATION WITH INFLAMMATORY RESPONSE AND DEVELOPMENT OF INFECTIOUS COMPLICATIONS
- Authors: Morozov S.A.1, Pronkina N.V.1, Starostina N.M.1, Leplina O.Y.1, Ostanin A.A.1, Shtobbe A.A.2, Chernykh E.R.1
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Affiliations:
- Research Institute of Fundamental and Clinical Immunology
- City Clinical Hospital № 1
- Issue: Vol 22, No 2-1 (2019)
- Pages: 423-425
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120237
- DOI: https://doi.org/10.31857/S102872210006918-4
- ID: 120237
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Abstract
The study has demonstrated a signifi cant increase in percentage of circulating CD4+CD25hi regulatory T cells and a decrease in Th1 (CD4+IFNγ+ N cells), as well as elevated leukocyte count, neutrophil-tolymphocyte ratio and CRP level during the first 24–48 hours after onset of ischemic stroke (IS). O note, patients with poststroke infection had less pronounced increase in CD4+CD25hi T-cells and the decrease in CD4+IFNγ+ T lymphocytes, while inflammatory response was significantly higher than in the opposite group. The largest difference between groups was observed when assessing the ratio of CD4+IFNγ+ and CD4+CD25hi T cells. The ratio of CD4+IFNγ+/ CD4+CD25hi in patients with infections was 3 times higher than in the group without infectious complications, correlated with the concentration of CRP (R = 0.54; p = 0.02) and the value of ratio > 1.14 allowed to predict infection with a specificity of 85.7% and a sensitivity of 68.8%.
About the authors
S. A. Morozov
Research Institute of Fundamental and Clinical Immunology
Author for correspondence.
Email: el-gorra@mail.ru
post-graduate student, laboratory of cellular immunotherapy,
Novosibirsk
Russian FederationN. V. Pronkina
Research Institute of Fundamental and Clinical Immunology
Head of laboratory of clinical immunology,
Novosibirsk
Russian FederationN. M. Starostina
Research Institute of Fundamental and Clinical Immunology
PhD, Head of Department of immunology,
Novosibirsk
Russian FederationO. Y. Leplina
Research Institute of Fundamental and Clinical Immunology
MD, Leading Researcher,
Novosibirsk
Russian FederationA. A. Ostanin
Research Institute of Fundamental and Clinical Immunology
MD, Chief Researcher,
Novosibirsk
Russian FederationA. A. Shtobbe
City Clinical Hospital № 1
PhD, Head of Department of neurilogy,
Novosibirsk
Russian FederationE. R. Chernykh
Research Institute of Fundamental and Clinical Immunology
MD, Corresponding Member of the Russian Academy of Sciences, Head of laboratory of cellular immunotherapy,
Novosibirsk
Russian FederationReferences
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