DEVELOPMENT OF A CANDIDATE SYNTHETIC VACCINE FOR IMMUNOTHERAPY OF MELANOMA
- 作者: Borobova E.A.1, Antonets D.V.1, Starostina E.V.1
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隶属关系:
- Federal Budgetary Research Institution State Research Center of Virology and Biotechnology «Vector»
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 1003-1005
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120236
- DOI: https://doi.org/10.31857/S102872210006491-5
- ID: 120236
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全文:
详细
Melanoma is the most dangerous skin cancer. It’s characterized by rapid growth rates and high incidences of metastasis. Melanoma cells have tumor antigens on their surfaces. Thereby, it’s possible to create an eff ective vaccine against melanoma. Earlier in the Federal Budgetary Research Institution State Research Center of Virology and Biotechnology «Vector» DNA-constructs, encoding artifi cial polyepitope immunogens MEL-A0201 and MEL-TCI, that consist of cytotoxic and helper T-cell epitope form six melanoma antigens, were created. This article includes the results of evaluation of the capability of designed DNA-constructs to induce antitumor immune response.
作者简介
E. Borobova
Federal Budgetary Research Institution State Research Center of Virology and Biotechnology «Vector»
编辑信件的主要联系方式.
Email: borobova-elena@rambler.ru
researcher,
Koltsovo, Novosibirsk region
俄罗斯联邦D. Antonets
Federal Budgetary Research Institution State Research Center of Virology and Biotechnology «Vector»
Email: fake@neicon.ru
PhD, senior researcher,
Koltsovo, Novosibirsk region
俄罗斯联邦E. Starostina
Federal Budgetary Research Institution State Research Center of Virology and Biotechnology «Vector»
Email: fake@neicon.ru
researcher,
Koltsovo, Novosibirsk region
俄罗斯联邦参考
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- Боробова Е. А., Антонец Д. В., Старостина Е. В., Смирнова О. Ю., Щербаков Д. Н., Волкова О. Ю., Орешкова С. Ф., Карпенко Л. И., Ильичев А. А., Бажан С. И. Кандидаты ДНК-вакцины против меланомы: дизайн, конструирование и оценка экспрессии целевых генов в эукариотических клетках. Новосибирский государственный университет. 2012, 10(5), 23–30.
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