CARACTERIZATION OF DISTRIBUTION OF MYELOID-DERIVED SUPPRESSOR CELLS AND MONOCYTES IN DIFFERENT CLINICAL VARIANTS OF ANKYLOSING SPONDYLITIS
- 作者: Morenkova A.Y.1, Tikchonova M.A.1, Sizikov A.E.1, Chumasova O.A.1, Sulutyan A.E.1, Chernykh E.R.1
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隶属关系:
- Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 420-422
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120235
- DOI: https://doi.org/10.31857/S102872210006917-3
- ID: 120235
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详细
The frequencies of myeloid-derived suppressor cell (MDSC) and monocyte subpopulations in patients with ankylosing spondylitis (AS) have been investigated. AS patients, especially with axial disease, had decreased proportion of granulocytic MDSC. In contrast, the frequencies of monocytic MDSC were signifi cantly increased. The proportion of non-classical monocytes was increased in AS patients without peripheral manifestations. Of note, non-classical monocyte levels positively correlated with disease activity.
作者简介
A. Morenkova
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
编辑信件的主要联系方式.
Email: morenkovasp@yandex.ru
Postgraduate Student, Laboratory of Cellular Immunotherapy,
Novosibirsk
俄罗斯联邦M. Tikchonova
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
Email: fake@neicon.ru
PhD (Biology), Senior Research Associate, Laboratory of Cellular Immunotherapy,
Novosibirsk
俄罗斯联邦A. Sizikov
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
Email: fake@neicon.ru
PhD, Head of Rheumatology Department,
Novosibirsk
俄罗斯联邦O. Chumasova
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
Email: fake@neicon.ru
PhD, rheumatologist, rheumatology department,
Novosibirsk
俄罗斯联邦A. Sulutyan
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
Email: fake@neicon.ru
PhD, rheumatologist, rheumatology department,
Novosibirsk
俄罗斯联邦E. Chernykh
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
Email: fake@neicon.ru
PhD, MD, Professor (Medicine), Corresponding Member, Russian Academy of Sciences, Head, Laboratory of Cellular Immunotherapy,
Novosibirsk
俄罗斯联邦参考
- Vanaki N., Aslani S., Jamshidi A., Mahmoudi M. Role of innate immune system in the pathogenesis of ankylosing spondylitis. Biomedicine & Pharmacotherapy. 2018, 105, 130–143.
- Boyette L. B., Macedo C., Hadi K., Elinoff B. D., Walters J. T., Ramaswami B., Chalasani G., Taboas J. M., Lakkis F. G., Metes D. M. Phenotype, function, and differentiation potential of human monocyte subsets. PLoS ONE. 2017, 12(4): e0176460.
- Bronte V., Brandau S., Chen S. H., Colombo M. P., Frey A. B., Greten T. F., Mandruzzato S., Murray P. J., Ochoa A., Ostrand-Rosenberg S., Rodriguez P. C., Sica A., Umansky V., Vonderheide R. H., Gabrilovich D. I. Recommendations for myeloid-derived suppressor cells nomenclature and characterization standarts. Nat Commun. 2016, 7: 12150.
- Liu Y. F., Zhuang K. H., Chen B., Li P. W., Zhou X., Jiang H., Zhong L. M., Liu F. B. Expansion and activation of monocytic-myeloid-derived suppressor cell via STAT3/ arginase-I signaling in patients with ankylosing spondylitis. Arthritis Research & Therapy. 2018,20(1):168.
- Guła Z., Stec M., Rutkowska-Zapała M., Lenart M., Korkosz M., Gąsowski J., Baran J., Baj-Krzyworzeka M., Szatanek R., Czyż J., Siedlar M. The absolute number of circulating nonclassical (CD14 + CD16 ++) monocytes negatively correlates with DAS28 and swollen joint count in patients with peripheral spondyloarthritis. Pilish Archives of internal medicine. 2017, 127 (12), 846–853.
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