THE EXPRESIION OF NCR RECEPTORS BY ENDOMETRIAL NATURAL KILLERS IN WOMEN WITH UTERINE LEIOMYOMA
- Authors: Malyshkina D.A.1, Antsiferova Y.S.2, Dolgushina N.V.1
-
Affiliations:
- B.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare of the Russian Federation
- Ivanovo’s Research Institute of Maternity and Childhood named after V. N. Gorodkov Ministry of Healthcare of the Russian, Ivanovo
- Issue: Vol 22, No 2-1 (2019)
- Pages: 391-393
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120097
- DOI: https://doi.org/10.31857/S102872210006907-2
- ID: 120097
Cite item
Full Text
Abstract
The patients with uterine leiomyoma demonstrate the signifi cant elevation of NKp44 and NKp46 expression by endometrial CD56+ lymphocytes. The high proliferation of leiomyoma is not associated with changes of NCR expression by endometrial NK. In the case of low proliferation the level of NK, CD56+NKp46+ and CD56+NKp46+NKp44+ lymphocytes is increased in comparison to the control group and group of patients with high expression of Ki67 in leiomyoma tissue.
Keywords
About the authors
D. A. Malyshkina
B.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare of the Russian Federation
Author for correspondence.
MD, Student,
Moscow
Russian FederationYu. S. Antsiferova
Ivanovo’s Research Institute of Maternity and Childhood named after V. N. Gorodkov Ministry of Healthcare of the Russian, Ivanovo
Email: niimid.immune@mail.ru
BD, Leadingscientific worker of the Laboratory of Clinical immunology,
Ivanovo
Russian FederationN. V. Dolgushina
B.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare of the Russian Federation
MD, PhD, Head of R&D Department,
Moscow
Russian FederationReferences
- Commandeur A. E., Styer A. K., Teixeira J. M. Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth. Hum Reprod Update. 2015, 21(5), 593–615.
- Antsiferova Y., Sotnikova N., Voronin D., Malyshkina A., Kirsanov A. Macrophages subsets in the endometrium of women with uterine leiomyoma. Am J Reprod Immunol. 2015, 73, Issue Supplement S1, 21.
- Pazina T., Shemesh A., Brusilovsky M., Porgador A., Campbell K. S. Regulation of the Functions of Natural Cytotoxicity Receptors by Interactions with Diverse Ligands and Alterations in Splice Variant Expression. Front Immunol. 2017, 30 (8),369.
- Миома матки / под ред. И. С. Сидоровой. – М.: МИА, 2003. – 256 с.
Supplementary files
