THE ROLE OF MACROPHAGES IN LOCAL REGULATION OF THE SYNTHETIC ACTIVITY OF INSULIN-SECRECTING PANCREATIC CELLS IN ALLOXANE DIABETES
- Authors: Bulavintseva T.S.1,2, Danilova I.G.1,2, Shmacova S.E.1,2
-
Affiliations:
- 1Ural Federal University
- Institute of Immunology and physiology UB RAS
- Issue: Vol 20, No 2 (2017)
- Pages: 267-269
- Section: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/119823
- ID: 119823
Cite item
Full Text
Abstract
On the alloxan diabetes model in rats, it was shown that exposure to monocytes / macrophages with an aminophthalhydroside derived drug leads to a decrease in monocyte infiltration and IL-1a in the pancreas. That promotes the preservation of insulin-producing cells and increases their synthetic activity.
Keywords
About the authors
T. S. Bulavintseva
1Ural Federal University; Institute of Immunology and physiology UB RAS
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
I. G. Danilova
1Ural Federal University; Institute of Immunology and physiology UB RAS
Email: noemail@neicon.ru
Russian Federation
S. E. Shmacova
1Ural Federal University; Institute of Immunology and physiology UB RAS
Email: noemail@neicon.ru
Russian Federation
References
- Type1 diabetes: Islet inflammation - the contribution of cytokines and beta-cells/ A. M. Gusdon, J. A. Corbett, C. E. Mathews// Drug Discovery Today: Disease Mechanisms.- 2006.- V3, № 13.- Р. 367-372.
- Morphological restructuring of myocardium during the early phase of experimental diabetes mellitus/ I. G. Danilova, P. A. Sarapultsev, S. U. Medvedeva, I. F. Gette,T. S. Bulavintceva,A. P. Sarapultsev//Anat. Rec. (Hoboken).- 2015.- V298, № 2.- P. 396-407. doi: 10.1002/ar.23052.
- Kumar G. L. Education guide. Immunohistochemical (IHC) staining methods / G. L. Kumar - Carpinteria, California: Dako North America, 2009.- 224р.
- Pulmonary injuries and cytokine levels afterthe intraperitoneal administration of pancreatic homogenates in rats/ G. Mozo, M. L. del Olmo, A. Caro-Paton, E. Reyes, L. Manzano, A. Belmonte, A. Almaraz, M. Alvarez-Mon // Rev. esp. enferm dig.- 2004.- V96., № 8.- P. 527-538.
- A tetrahydrophthalazine derivative 'sodium nucleinate» exerts a potent suppressive effect upon LPS-stimulated mononuclear cells in vitro and in vivo/ T. Jukic, M. Abidov, A. Ihan// Οίπ. Antropol.-2011.- V 35, № 4.- Р.1219-23.
Supplementary files
