THE INFLUENCE OF RECOMBINANT INTERLEUKIN 1-β ON CYTOKINE PROFILE OF MIXED SALIVA OF PATIENTS WITH COMPLICATED FRACTURES OF THE MANDIBLE

In the research we have analyzed of the cytokine profile of mixed saliva of patients with complicated fractures of the mandible. Studied the levels of proinflammatory and anti-inflammatory cytokines and their dynamics in the treatment process with the conventional schemes and additional treatment with recombinant IL-1β. Indicators of the level of cytokines (Il-1-β, IL-2, Il-4, Il-8, Il-10, and TNFα) in mixed saliva were determined before treatment and 10-12 days of therapy. The study identified the initial increase of proinflammatory cytokines IL-β and IL-8 in all patients, which may indicate the tension of the local immunity in response to trauma. Patients receiving additional immunotherapy, these parameters returned to normal, and level of TNFa was increased, suggesting a high adaptive capacity of the local level of the immune system at use of Betaleukin.

цитокины, переломы нижней челюсти, беталейкин, cytokines, mandibular fractures, Betaleukin