THE PROLONGATED EFFECTS OF BETA-ENDORPHIN ON MOUSE IL-1BETA, IL-2, IL-4 AND IL-10 SECRETION IN VIVO
- Authors: Baeva T.A.1, Tendryakova S.P.1,2
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms
- Perm State University
- Issue: Vol 20, No 2 (2017)
- Pages: 246-248
- Section: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/119777
- ID: 119777
Cite item
Abstract
Beta-endorphin is a compound of peptide nature with a high regulatory activity on the immune system. The existence of long-term immunoregulatory effects of beta-endorphin is of great interest.This work describes the beta-endorphin effects on the corticosterone levels in plasma, as well as the production of key regulatory cytokines by murine splenocytes and macrophages. The dependence of the beta-endorphin effects from the used dose and exposure time was shown.
Keywords
About the authors
T. A. Baeva
Institute of Ecology and Genetics of Microorganisms
Author for correspondence.
Russian Federation
S. P. Tendryakova
Institute of Ecology and Genetics of Microorganisms; Perm State UniversityRussian Federation
References
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- Гейн С. В., Баева Т. А., Небогатиков В. О., Тендрякова С. П. Влияние бета-эндорфина на антителогенез, пролиферацию и секрецию Tх1/Tх2-цитокинов in vivo. Бюллетень экспериментальной биологии и медицины, 2011, 11,526-529.
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