EFFECT OF THE AUTOLOGOUS APOPTOTIC CELL CULTURES ON THE PARAMETERS OF EARLY AND LATE APOPTOSIS OF T LYMPHOCYTES FROM HEALTHY DONORS
- Authors: Abramova T.Y.1, Tsura V.A.1, Blinova E.A.1, Kozlov V.A.1
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Affiliations:
- Federal state budgetary organization "Research Institute of Fundamental and Clinical Immunology"
- Issue: Vol 20, No 2 (2017)
- Pages: 236-238
- Section: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/119753
- ID: 119753
Cite item
Abstract
In healthy people, it has been established the possibility of induction of early and late apoptosis of T-lym-phocytes proliferated in vitro under physiological conditions through the transfer of both the cellular and humoral components of an autologous apoptotic T cell culture. It was determined that under equal conditions of cultivation of lymphocytes: a high cell density and a depletion of the culture medium, the transfer of components of the cells stimulated by anti-CD3 antibodies regularly increased the sensitivity of T-lymphocytes to apoptosis. While transfer of components of the culture with the dexamethasone exerted a modulating effect.
About the authors
T. Ya. Abramova
Federal state budgetary organization "Research Institute of Fundamental and Clinical Immunology"
Author for correspondence.
Russian Federation
V. A. Tsura
Federal state budgetary organization "Research Institute of Fundamental and Clinical Immunology"Russian Federation
E. A. Blinova
Federal state budgetary organization "Research Institute of Fundamental and Clinical Immunology"Russian Federation
V. A. Kozlov
Federal state budgetary organization "Research Institute of Fundamental and Clinical Immunology"Russian Federation
References
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