EXPERIMENTAL AND THEORETICAL STUDY MECHANISMS OF THE IDIOTYPIC REGULATION OF AUTOIMMUNE REACTION INDUCED BY ALLOANTIGEN

Injection of allogeneic erythrocytes to mice leads to the development of anemia, the appearance of antibodies specific to RE, whose production coincides with the production of anti-erythrocyte autoantibodies and are characterized by progressive growth. The results of computer studies have been shown that the similarities between theoretical and experimental kinetics were achieved by applying a signal to the clone located as far from the autoreactive clone as possible in the investigated fragment of the immune network. Herewith, all clones of the immune network fragment demonstrate a progressive, continual growth of activity, that indicates a breakdown in the state of tolerance. Thus, the emergence of systemic chronic autoimmune processes may be the result of an immune response to antigens that activate lymphocytes, which specificity is similar but not identical to the specificity of lymphocytes recognizing autoantigens.

иммунная сеть, аутоиммунная гемолитическая анемия, математическая модель, иммунорегуляция, immune network, autoimmune hemolytic anemia, mathematic model, immuno-regulation