DETERMINATION OF THE LEVEL OF CD64 ON NEUTROFILES IN PATIENTS WITH SURGICAL SEPSIS
- 作者: Lazanovich V.1, Кostyushko A.1, Shumatov V.1
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隶属关系:
- Federal State Budget Educational Institute of higher professional education Pacific State Medical University of Ministry of health Russian Federation
- 期: 卷 22, 编号 4 (2019)
- 页面: 1494-1496
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119610
- DOI: https://doi.org/10.31857/S102872210007069-0
- ID: 119610
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The level of the expression of CD64 on neutrophils by fl ow cytometry in 49 patients with sepsis was studied, the dependence of these parameters on the degree of severity of the condition on the scale APACHEII (in points), the severity of multiple organ dysfunction scale SOFA (in points).High-level of expression on neutrophils nCD64 directly correlated with more severe organ dysfunction (SOFA), the weight of the state (APACHEII). These results may give the suggestion that presence of CD64 on neutrophils may serve as a biomarker refl ecting on the degree of systemic infl ammation in sepsis and may be a criterion in the prediction of the severity of disease and outcome in patients with sepsis.
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作者简介
V. Lazanovich
Federal State Budget Educational Institute of higher professional education Pacific State Medical University of Ministry of health Russian Federation
编辑信件的主要联系方式.
Email: immuno2003@mail.ru
Ph.D., assistant professor, Department of normal and Pathological Physiology,
Vladivostok
俄罗斯联邦A. Кostyushko
Federal State Budget Educational Institute of higher professional education Pacific State Medical University of Ministry of health Russian Federation
Email: fake@neicon.ru
Ph.D., assistant professor, Department of normal and Pathological Physiology,
Vladivostok
俄罗斯联邦V. Shumatov
Federal State Budget Educational Institute of higher professional education Pacific State Medical University of Ministry of health Russian Federation
Email: fake@neicon.ru
Doctor of Sciences, Professor of the Department of intensive care, anesthesiology, intensive care and emergency medical services,
Vladivostok
俄罗斯联邦参考
- Hsu K. H., Chan M. C., Wang J. M. et al. Comparison of Fcγ receptor expression on neutrophils with procalcitonin for the diagnosis of sepsis in critically ill patients. Respirology. 2011; 16(1), 152–60.
- Icardi M., Erickson Y., Kilborn S. et al. CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients. J. Clin. Microbiol. 2009; (47): 3914–3919.
- Singer M., Deutschman S., Seymour C. W., ShankarHari M., Annane D., Bauer M et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315 (8), 801–810.
- Stevenson E. K., Rubenstein A. R., Radin G. T., Wiener R. S., Walkey A. J. Two decades of mortality trends among patients with severe sepsis: a comparative metaanalysis. Crit Care Med. 2014;42, 625–631.
- Venet F., Lepape A. Clinical review: flow cytometry perspectives in the ICU – from diagnosis of infection to monitoring of injury-induced immune dysfunctions. Crit. Care. 2011; 15(5), 231.
