MICROBIOLOGICAL AND IMMUNOLOGICAL ASPECTS OF THE INTERACTION OF PSEUDOMONASAERUGINOSA,STAPHYLOCOCCUSAUREUS AND ESCHERICHIACOLI WITH NANOSCALE METAL PARTICLES, RECIEVED FROM THE SURFACE OF DENTAL IMPLANTS

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Abstract

The purpose of this study was to investigate the interaction of nanosized metal particles obtained in the laboratory from the surface of Nobel Biocare dental implants with Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli in the presence of native and heat inactivated human serum. In vitro experiments it was established that when nanoparticles were added to test samples of native sera, the accumulated biomass of S. aureus and E. coli was increased by 8.1-8.3 % in broth culture and P aeruginosa by 42.9 % in Comparison of control, indicating that they inhibited the bactericidal effect of the complement system. In addition, the potentiating effect of native serum on biofilm formation of bacteria on the surface of nanoparticles was recorded. Possible immunological consequences of interaction in the system "nanoparticle-whey protein-bacteria in the process of osseointegration" are discussed.

About the authors

V. V. Labis

Moscow State University of Medicine and Dentistry named after A. I. Evdokimov

Author for correspondence.
Russian Federation

E. A. Bazikyan

Moscow State University of Medicine and Dentistry named after A. I. Evdokimov

Russian Federation

I. G. Kozlov

Russian National Research Medical University named by N. I. Pirogov

Russian Federation

S. V. Sizova

Institute of Bioorganic Chemistry named by Academicians M. M. Shemyakin and Y. A. Ovchinnikov, RAS

Russian Federation

S. V. Khaidukov

Institute of Bioorganic Chemistry named by Academicians M. M. Shemyakin and Y. A. Ovchinnikov, RAS

Russian Federation

N. V. Nemtseva

Institute for Cellular and Intracellular Symbiosis UrB RAS

Russian Federation

A. V. Gritsenko

Institute for Cellular and Intracellular Symbiosis UrB RAS; Orenburg Scientific Centre UrB RAS

Russian Federation

References

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  3. Лабис В. В., Базикян Э. А., Козлов И. Г., Сизова С. В., Хайдуков С. В. Наноразмерные частицы - участники остеоинтеграции // Бюллетень Оренбургского научного центра УрО РАН. 2016. 1: 1-18.
  4. Лабис В. В., Базикян Э. А., Сизова С. В., Хайдуков С. В., Козлов И. Г. Исследование наноразмерных частиц, полученных в супернатантах с дентальных имплантатов двух систем А и В // Бюллетень Оренбургского научного центра УрО РАН. 2016. 2: 16с.

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Copyright (c) 2017 Labis V.V., Bazikyan E.A., Kozlov I.G., Sizova S.V., Khaidukov S.V., Nemtseva N.V., Gritsenko A.V.

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