HISTAMINLIBERATION AND CD45 DYNAMIC IN DRUG HYPERSENSITIVITY (DHS) PATIENTS
- Authors: Vasneva Z.P.1, Mokeeva M.V.1
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Affiliations:
- Samara Diagnostic Centre
- Issue: Vol 22, No 4 (2019)
- Pages: 1438-1440
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119480
- DOI: https://doi.org/10.31857/S102872210007050-0
- ID: 119480
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Abstract
The leucocyte specific activations on the dynamic expression of CD45-antigen (CD45-test) by the flow cytometry, the leucocyte histaminliberation nonspecific and specific (to the local anaesthetics (LA)) in the DHS patients were assessed in vitro. The leucocyte activation in the DHS patients was revealed in 80% by CD45- test. Increased spontaneous leucocyte histaminliberation – in 36,4%, nonspecific stimulated – 67,7%, LA-stimulated – 27,3% pts. КСCD45 were correlated with spontaneous histaminliberation (r = – 0,46, р=0,002), stimulated histamineliberation (r = – 0,43, р=0,013) и LA-stimulated histamineliberation (r = – 0,28, p = 0,07).
About the authors
Zh. P. Vasneva
Samara Diagnostic Centre
Author for correspondence.
Email: vasneva@list.ru
PhD, laborant doctor,
Samara
Russian FederationM. V. Mokeeva
Samara Diagnostic Centre
Email: fake@neicon.ru
PhD, doctor,
Samara
Russian FederationReferences
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