A role of single nucleotide polymorphism in TNF, NOS3 and MMP9 genes at the risk of developing neonatal pneumonia
- 作者: Meremianina E.A.1,2, Svitich O.A.1,3, Alieva A.I.4, Sobolev V.V.1
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隶属关系:
- I. Mechnikov Research Institute for Vaccines and Sera
- Russian Medical Academy of Continuing Professional Education
- First Moscow State I. Sechenov Medical University (Sechenov University)
- Dagestan State Medical Academy
- 期: 卷 23, 编号 3 (2020)
- 页面: 257-262
- 栏目: SHORT COMMUNICATIONS
- URL: https://journals.rcsi.science/1028-7221/article/view/119427
- DOI: https://doi.org/10.46235/1028-7221-346-ARO
- ID: 119427
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全文:
详细
Neonatal pneumonia is one of the most common causes of infant mortality. Moreover, the diagnosis of this pathology represents a difficult task and requires to seek for additional solutions in clinical and laboratory practice. One of the current and promising ways to diagnose rerlies on search of predictive markers among the innate and adaptive immunity genes involved in disease pathogenesis. We used bioinformatics analysis to select genes playing essential role developing neonatal pneumonia. Next, cord blood samples collected from 234 newborns were examined by real-time polymerase chain reaction for nine polymorphic markers in the TNF, IL10, IL17A, IL17F, IL6, NOS3, and MMP9 genes. The results of statistical analysis showed that heterozygous genotypes in the MMP9 and TNF genes were associated with the risk of developing early neonatal pneumonia, and also the protective role of homozygotes AA in the MMP9 gene and GG in the TNF gene. A search for associations with a risk of intrauterine pneumonia revealed an unfavorable role for heterozygous genotypes in the NOS3 and MMP9 genes. Thus, due to difficulties in diagnosis or in case of developing neonatal pneumonia, it may be recommended to add genetic analysis for assessing polymorphic markers in the MMP9 (rs17576), TNF (rs1800629) and NOS3 (rs1549758) genes along with standard test assays.
作者简介
E. Meremianina
I. Mechnikov Research Institute for Vaccines and Sera; Russian Medical Academy of Continuing Professional Education
编辑信件的主要联系方式.
Email: ekatterine@gmail.com
Meremianina Ekaterina A. - PhD (Medicine), Junior Research Associate, Laboratory of Molecular Immunology; Senior Lecturer, Department of Virology
105064, Moscow, Maly Kazenny lane, 5a
Phone: 7 (926) 184-14-89
俄罗斯联邦O. Svitich
I. Mechnikov Research Institute for Vaccines and Sera; First Moscow State I. Sechenov Medical University (Sechenov University)
Email: fake@neicon.ru
PhD, MD (Medicine), Corresponding Member, Russian Academy of Sciences, Professor, Department of Microbiology, Virology and Immunology; Director
Moscow
俄罗斯联邦A. Alieva
Dagestan State Medical Academy
Email: fake@neicon.ru
PhD, MD (Medicine), Associate Professor, Dean, Faculty of Medicine and Prevention
Makhachkala, Republic of Dagestan
俄罗斯联邦V. Sobolev
I. Mechnikov Research Institute for Vaccines and Sera
Email: fake@neicon.ru
PhD (Biology), Senior Research Associate, Laboratory of Molecular Immunology
Moscow
俄罗斯联邦参考
- Антонов А.Г., Арестова Н.Н., Байбарина Е.Н. Неонатология: национальное руководство / Под ред. Н.Н. Володина. М.: ГЭОТАР-Медиа, 2009. 848 c. [Antonov A.G., Arestova N.N., Baybarina E.N. Neonatology: national guideline. Ed. by N.N. Volodin]. Мoscow: GOETAR-Media, 2009. 848 p.
- Журавлева Л.Н., Новикова В.И. Показатели врожденного иммунитета при пневмониях у новорожденных // Охрана материнства и детства, 2018. № 2 (32). С. 27-31. [Zhuravleva L.N., Novikova V.I. System of congenital immunity in pneumonia in newborns. Okhrana materinstva i detstva = Maternal and Child Health, 2018, no. 2 (32), pp. 27-31. (In Russ.)]
- Bellanti J.A., Zeligs B.J. Current concepts of immune interventions in children with respiratory diseases. Respiration, 1994, Vol. 61, no. 1, pp. 3-7.
- Fattakhov N., Smirnova L., Atochin D., Parshukova D., Skuratovskaia D., Painter Q., Zatolokin P., Semke A., Litvinova L., Ivanova S. Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and metabolic syndrome in healthy subjects and schizophrenia patients. Int. J. Obes. (Lond), 2018, Vol. 42, no. 12, pp. 2036-2046.
- Feng B., Mao Z-R, Pang K., Zhang S-L., Li L. Association of tumor necrosis factor v -308G/A and interleukin-6 -174G/C gene polymorphism with pneumonia-induced sepsis. J. Crit. Care, 2015, Vol. 30, no. 5, pp. 920-923.
- GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, allcause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet, 2016, Vol. 388, no. 10053, pp. 1459-1544.
- Jeoung J.W., Kim D.M., Oh S., Lee J-S., Park S.S., Kim J.Y. The relation between endothelial nitric oxide synthase polymorphisms and normal tension glaucoma. J. Glaucoma, 2017, Vol. 26, no. 11, pp. 1030-1035.
- Qidwai T., Khan F. Tumour necrosis factor gene polymorphism and disease prevalence. Scand. J. Immunol., 2011, Vol. 74, no. 6, pp. 522-547.
- Wu M.Y., Wu Y., Zhang Y., Liu C.Y., Deng C.Y., Peng L., Zhou L. Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis. BMC Ophthalmol., 2017, Vol. 17, no. 1, 48. doi: 10.1186/s12886-017-0442-2.
- Zhang Y., Cao Y., Xin L., Gao N., Liu B. Association between rs1800629 polymorphism in tumor necrosis factor-v gene and dilated cardiomyopathy susceptibility: Evidence from case-control studies. Medicine (Baltimore), 2018, Vol. 97, no. 50, e13386. doi: 10.1097/MD.0000000000013386.
- Zhao F., Fan Z., Huang X. Role of matrix metalloproteinase-9 gene polymorphisms in glaucoma: a hospitalbased study in chinese patients. J. Clin. Lab. Anal., 2020, Vol. 34, no. 3, e23105. doi: 10.1002/jcla.23105.
- Zhou H., Zhu X. Association between matrix-metalloproteinase polymorphisms and prostate cancer risk: a meta-analysis and systematic review. Cancer Manag. Res., 2018, Vol. 10, pp. 5247-5259.
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