Стволовые клетки пуповинной крови: перспективы трансплантации в неврологической практике
- Авторы: Газизов И.М.1, Измайлов А.А.1, Елагина Э.А.2, Сафиуллов З.З.1
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Учреждения:
- Казанский государственный медицинский университет
- ООО «Авиценна-Эндокринология»
- Выпуск: Том LVI, № 2 (2024)
- Страницы: 181-196
- Раздел: Обзоры
- URL: https://journals.rcsi.science/1027-4898/article/view/264218
- DOI: https://doi.org/10.17816/nb626625
- ID: 264218
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Аннотация
Пуповинная кровь прошла долгий путь от клеточных/тканевых отходов, получаемых после родов, до ценного биологического материала с широким регенераторным потенциалом. На сегодняшний день гемопоэтические стволовые клетки пуповинной крови наравне с костным мозгом и мобилизованной периферической кровью применяют в рамках медицинского стандарта для лечения гемобластозов и наследственных заболеваний крови. Накапливается всё больше экспериментальных данных о возможности применения клеточных фракций пуповинной крови для лечения негематологических заболеваний и, в частности, заболеваний центральной нервной системы. Актуальной проблемой клеточной терапии болезней центральной нервной системы, включающих ишемические и травматические повреждения, а также нейродегенеративные заболевания, остаётся выбор клеточного материала для нейротрансплантации. Стволовые или зрелые соматические клетки, подготовленные для нейротрансплантации, должны иметь предсказуемые и воспроизводимые характеристики, отвечающие поставленной терапевтической цели: трофическое и/или нейропротективное действие для повышения жизнеспособности нейронов в области повреждения; стимулирование роста и миелинизации аксонов; восстановление клеточного матрикса или дифференцировка в заданном направлении для замещения утраченного пула клеток головного или спинного мозга. Тот факт, что в составе пуповинной крови присутствуют не только гемопоэтические, но и различные негемопоэтические стволовые клетки с широким регенераторным потенциалом, стал основой активного использования этих клеток для нейротрансплантации. В предлагаемом обзоре приведены исторические сведения о внедрении в практическую медицину пуповинной крови, её клеточном составе и клинических применениях различных типов стволовых клеток для лечения болезней центральной нервной системы у детей, таких как ишемическая энцефалопатия, инсульт, кровоизлияния в мозг, детский церебральный паралич, аутизм, а у взрослых — для лечения инсульта, травмы спинного мозга и нейродегенеративных заболеваний.
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Ильназ Марселевич Газизов
Казанский государственный медицинский университет
Email: ilnazaziz@mail.ru
ORCID iD: 0000-0003-3396-8643
SPIN-код: 4219-6480
канд. мед. наук, доц., зав. каф., каф. нормальной анатомии
Россия, КазаньАндрей Александрович Измайлов
Казанский государственный медицинский университет
Email: gostev.andrei@mail.ru
ORCID iD: 0000-0002-8128-4636
SPIN-код: 9629-8511
канд. мед. наук, зав. лабораторией молекулярной и клеточной медицины
Россия, КазаньЭльмира Абдулхаковна Елагина
ООО «Авиценна-Эндокринология»
Email: elaginabsk@yandex.ru
ORCID iD: 0000-0002-4598-1688
SPIN-код: 1440-4782
преподаватель, клин. мед. психолог
Россия, КазаньЗуфар Зуфарович Сафиуллов
Казанский государственный медицинский университет
Автор, ответственный за переписку.
Email: redblackwhite@mail.ru
ORCID iD: 0000-0003-4577-3448
SPIN-код: 6987-9144
канд. мед. наук, доц., каф. нормальной анатомии
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