Email this article Significance of diphtheria toxin in neuropathy development and protective effect of nerves growth factor
- Authors: Sorokina М.N.1, Davydovskay М.V.1, Romanjuk А.V.1, Chalisova N.I.1, Skripchenko N.V.1, Nasyrov R.А.1, Aksenov О.A.1, Markova О.А.1
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Affiliations:
- Research Institute of Children's Infections
- Issue: Vol XXX, No 3-4 (1998)
- Pages: 46-49
- Section: Articles
- URL: https://journals.rcsi.science/1027-4898/article/view/81048
- DOI: https://doi.org/10.17816/nb81048
- ID: 81048
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Abstract
In experiments in vitro and in vivo competitive relationships of diphtheria toxin and nerves growth factor were shown: in organotypical culture (300 sensor ganglions) and in model of experimental diphtheria neuropathy in 66 white rats. There were given evidences of protective action of nerves growth factor, inhibiting the toxic effect of diphtheria toxin. Contents of free toxin and specific immune comlexes was studied in 25 children with diphtheria polyneuropathy. Favourable outcome of disease was observed in children with high presence of nerves growth factor in blood serum, thus giving new approach in treatment of nervous system diseases.
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##article.viewOnOriginalSite##About the authors
М. N. Sorokina
Research Institute of Children's Infections
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
М. V. Davydovskay
Research Institute of Children's Infections
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
А. V. Romanjuk
Research Institute of Children's Infections
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
N. I. Chalisova
Research Institute of Children's Infections
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
N. V. Skripchenko
Research Institute of Children's Infections
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
R. А. Nasyrov
Research Institute of Children's Infections
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
О. A. Aksenov
Research Institute of Children's Infections
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
О. А. Markova
Research Institute of Children's Infections
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
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