Email this article Cytokines and monoamines in pathogenesis of multiple sclerosis
- Authors: Khaidarov B.T.1,2,3, Kuznetsov V.Р.1,2,3, Zakharova М.N.1,2,3, Belyaev D.L.1,2,3, Barhatova V.P.1,2,3, Brusov О.S.1,2,3, Babayants А.А.1,2,3, Askarova L.S.1,2,3, Konysova А.D.1,2,3, Zavalishin I.A.1,2,3
-
Affiliations:
- Research Institute of Neurology, Russian Academy of Medical Sciences
- Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS
- VTSPZ RAMS
- Issue: Vol XXVIII, No 3-4 (1996)
- Pages: 5-9
- Section: Articles
- URL: https://journals.rcsi.science/1027-4898/article/view/79635
- DOI: https://doi.org/10.17816/nb79635
- ID: 79635
Cite item
Full Text
Abstract
The article presents the results of research of cytokines (α- and ß-interferons and tumor necrosis factor-а) and monoamines (adrenalin, noradrenalin, dopamin, serotonin) in blood and cerebrospinal fluid in 151 patients with multiple sclerosis. The correlation between immune, biochemical changes and clinical activity and course of disease were revealed. The immunocorrection with α-interferon is recommended.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
B. T. Khaidarov
Research Institute of Neurology, Russian Academy of Medical Sciences; Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS; VTSPZ RAMS
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
V. Р. Kuznetsov
Research Institute of Neurology, Russian Academy of Medical Sciences; Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS; VTSPZ RAMS
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
М. N. Zakharova
Research Institute of Neurology, Russian Academy of Medical Sciences; Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS; VTSPZ RAMS
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
D. L. Belyaev
Research Institute of Neurology, Russian Academy of Medical Sciences; Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS; VTSPZ RAMS
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
V. P. Barhatova
Research Institute of Neurology, Russian Academy of Medical Sciences; Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS; VTSPZ RAMS
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
О. S. Brusov
Research Institute of Neurology, Russian Academy of Medical Sciences; Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS; VTSPZ RAMS
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
А. А. Babayants
Research Institute of Neurology, Russian Academy of Medical Sciences; Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS; VTSPZ RAMS
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
L. S. Askarova
Research Institute of Neurology, Russian Academy of Medical Sciences; Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS; VTSPZ RAMS
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
А. D. Konysova
Research Institute of Neurology, Russian Academy of Medical Sciences; Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS; VTSPZ RAMS
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
I. A. Zavalishin
Research Institute of Neurology, Russian Academy of Medical Sciences; Research Institute of Epidemiology and Microbiology named after V.I. acad. N.F. Gamalei RAMS; VTSPZ RAMS
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
References
- Зимина И.В., Лопухин Ю.М., Арион В.Я. Кожа как иммунный орган: Клеточные элементы и цитокины // Иммунология.—1994.—№ 1.—С.8—13.
- Benveniste E.N. Inflammatory cytokines within central nervous system: sources, function and mechanism of action // An. J. Physiol.—1992—Vol.263.-P. 1—16.
- Benvenuto R., Parolli M., Buttinelle C. Tumor necrosis factor alpha and interferon-gamma synthesis by cerebrospinal fluidderived T-cell clones in multiple sclerosis // Ann. N. J. Acad. Sсi.—1992,—Vol.690.—P.341—346.
- Chelmicka-Schorr E. et. al. Chemical sympathectomy augments the severity of experimental allergic encephalomyelids // J. Neuroimmunol.—1988.—Vol. 17,—P.347—350.
- Chelmicka-Schorr E., Arnason B.G. Nervous system — Immune system interactions and their role in multiple sclerosis // Annals of neurol.—1994.—Vol.36.—P.29—33.
- Ellison J.W. et al. Design Strategies in Multiple Sclerosis Clinical Trials // Annals of neurology.—1994.—Vol.36.— P.108—113.
- Jacobs L., Johnson K.P. A brief history of tne use of interferons as treatment of multiple sclerosis // Arch. Neurol.—
- . —Vol. 51—P.1245—1252.
- Hartung H.P. et al. Circulating adhesion molecules and inflammatory, mediators in demyelination // Neurology.—
- —Vol.45.—P.22—32.
- Heyes M.P. Lackner A. AIDS-dementia and excitotoxicity // J. Neurochem.—1992— Vol.55.—P.338—341.
- Ignarro L.J. Nitric Oxide // Hypotension.—1990.— Vol. 16.—P.477—483.
- Karaszevski J.W., Reder A., Anlas B., Arnason B. Increased high affinity beta-adrenergic receptor densities and cyclic AMP responses of CD8 cells in multiple sclerosis // J. Neuroimmunol.—1993.—Vol.43.—P. 1—8.
- Medenda R.F. et al. Plasmapheresis combined with interferon: an effective therapy for multiple sclerosis // J. Clin.—Apheresis.—1994— Vol.9.—P.222—227.
- Me Carthy K.D., Salm A. Astroglial receptors and their regulation of intermediate filament protein phosphorylation // Glial and Cell Receptor.—CD. H.Kimetberg; New York: Raven Press.—1989.—P.1—23.
- Raine C.S. The Immunology of the multiple sclerosis // Annals of Neurol.—1994.—Vol.36.—P.61—73.
- Ransohoff R.M., Estes M.L. Astrocyte expression of major histocompatibility complete gene products in multiple sclerosis brain tissue obtained by stereotactic biopsy // Arch. Neurol.—1991.—Vol.48.-P. 1244—1246.
- Werner H. et al. Interaction between lymphocytes and neurotransmitters // Annals of the New York Academy of Sciences—1988,—Vol.496.—P.312— 316.
- Whitaker J.N. Rationale for immunotherapy in multiple sclerosis // Annals of Neurol.—1994.—Vol.36.— P. 103—108.
