ULTRASTRUCTURAL CHANGES IN AXON-DENDRITIC SYNAPSES OF CA1 OF HIPPOCAMPUS UNDER 96-HOUR PARADOXIAL SLEEP DEPRIVATION
- Authors: Abushov B.M1
-
Affiliations:
- A.I. Karajev Physiology Institute of NAS
- Issue: Vol XLIII, No 3 (2011)
- Pages: 8-10
- Section: Articles
- URL: https://journals.rcsi.science/1027-4898/article/view/13659
- DOI: https://doi.org/10.17816/nb13659
- ID: 13659
Cite item
Full Text
Abstract
With the application of electron microscope technique the morphology of axon-dendritic synapses in area CA1 of rat hippocampus under 96-hour paradoxical sleep deprivation has been studied. On the basis of quantitative and qualitative-morphometric analysis it has been stated that the ultrastructure of the components of most symmetrical and asymmetrical axon-dendritic synapses were deeply affected in response to the 96-hour paradoxical sleep deprivation. The revealed ultrastructural alterations in axon-dendritic synapses of CA1 area can be considered as synaptic level of disturbances of neurophysiological mechanisms of learning and memory processes.
About the authors
Babek M Abushov
A.I. Karajev Physiology Institute of NAS
Email: babushov@rambler.ru
Лаборатория функциональной цитохимии; Институт физиологии им. А.И. Караева НАН; A.I. Karajev Physiology Institute of NAS
References
- Лакин Г.Ф. Биометрия. - М., 1990.
- Семченко В.В., Степанов С.С., Боголепов Н.Н. Пластичность синапсов головного мозга. - Омск, 2008.
- Brankaиk J., Platta B., Riedel G. // Progr. Neuro-Psychopharmacol. Biol. Psychiat. -2009. - Vol . 33. - P. 806-812.
- Jouvet M. // Progr. Brain Res. - 1965. - Vol. 18. - P. 257-258.
- Kasai H., Fukuda M., Watanabe S. // Tren. Neurosci. - 2010. - Vol. 33. - P. 121-129.
- Kim E.Y., Mahmoud G.S., Grover L.M. // Neurosci. Let. - 2005. - Vol. 388, № 3. -P. 163-167.
- Morgado-Bernal I. // Neuroscience. - 2011. - Vol. 176. - P. 12-19.
- Penzes P., Jones K.A. Tren. Neurosci. - 2008. - Vol. 31. - P. 419-427.
- Ruskin D.N., LaHostea G.J. // Behav. Brain Res. - 2008. - Vol. 191. - P. 67-71.
- Sweatt J.D. Mechanisms of Memory. - N. Y., Elsevier LTD, 2010.
- Walker M.P. // Progr. Brain Res. - 2010. - Vol.185. - P. 49-68.
- Yang R.H., Hu S.J., Wang Y. et al. // Brain Res. - 2008. - Vol.1230. - P. 224-232.