Synthesis, Characterization, in vitro Antifungal Activities and Calf Thymus DNA Interactions of Two Different Hydroxy Benzaldehyde Derivative Schiff Bases from Sulfamethizole: Electrochemical, Spectroscopic and Biological Study
- Autores: Biçer E.1, Pehlivan V.1, Bekiroğlu Y.G.2
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Afiliações:
- Department of Chemistry, Faculty of Arts and Sciences
- Department of Herbal and Animal Production, Bafra Vocational School
- Edição: Volume 55, Nº 5 (2019)
- Páginas: 419-428
- Seção: Article
- URL: https://journals.rcsi.science/1023-1935/article/view/192156
- DOI: https://doi.org/10.1134/S1023193519050045
- ID: 192156
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Resumo
In the present work, the Schiff bases were synthesized by reacting sulfamethizole (SMTZ) with two different hydroxy benzaldehydes (2,3-dihydroxy benzaldehyde (DHBA) and 2,4,6-trihydroxy benzaldehyde (THBA)) and characterized by elemental analysis, 1H-NMR and IR spectroscopies. From the obtained data, it was suggested that 4,6-dihydroxy salicylaldehyde reacted with both primary and secondary amine groups of SMTZ. The binding properties between the synthesized Schiff bases and calf thymus DNA (CT-DNA) at the physiological pH (7.4) was investigated by using cyclic voltammetry and UV-Vis spectroscopy techniques. The experimental results verify that the Schiff bases can bind to CT-DNA by electrostatic mode in 1 : 1 stoichiometry. Antifungal activities of the synthesized Schiff bases against Candida albicans ATCC 10231 were studied and their minimum inhibitory concentrations (MIC) were also determined. The MIC value of the Schiff base 1 synthesized from DHBA is smaller than that of the Schiff base 2 obtained from THBA. Although Schiff base 2 binds to CT-DNA with a higher affinity than Schiff base 1, it is less effective than Schiff base 1 against Candida albicans.
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Sobre autores
Ender Biçer
Department of Chemistry, Faculty of Arts and Sciences
Autor responsável pela correspondência
Email: ebicer@omu.edu.tr
Turquia, Atakum-Samsun, 55139
Vahide Pehlivan
Department of Chemistry, Faculty of Arts and Sciences
Email: ebicer@omu.edu.tr
Turquia, Atakum-Samsun, 55139
Yeliz Bekiroğlu
Department of Herbal and Animal Production, Bafra Vocational School
Email: ebicer@omu.edu.tr
Turquia, Bafra-Samsun, 55400
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