Anodic Voltammetric Determination of an Atypical Antipsychotic Drug Amisulphide in Pharmaceutical Dosage Forms Using Electrochemical fsDNA Biosensor
- 作者: Cesme M.1, Polat D.1, Senel P.2, Golcu A.2
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隶属关系:
- Faculty of Art and Sciences, Department of Chemistry
- Faculty of Arts and Sciences, Department of Chemistry
- 期: 卷 55, 编号 4 (2019)
- 页面: 281-290
- 栏目: Article
- URL: https://journals.rcsi.science/1023-1935/article/view/192028
- DOI: https://doi.org/10.1134/S1023193519030042
- ID: 192028
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详细
In this study, a new biosensor for amisulpride (ASP) determination is defined. The interaction between ASP and fish sperm double-stranded DNA (FSdsDNA) was examined by differential pulse voltammetry (DPV) method utilizing FSdsDNA modified pencil graphite electrode (PGE). Sensitive and reliable ASP determination and detection was performed in pH 4.80 acetate buffer (20% ethanol) before and after the interaction of ASP and FSdsDNA, acting by the change in guanine oxidation signals from the electro-active bases of FSdsDNA. In addition, analytical method validity tests were examined in this study. This modified electrode have used in 1–10 μg/mL determination interval for the quantitative determination of ASP in pharmaceutical forms and the limit of detection (LOD) has been found as 0.46 μg/mL. Also, the binding constants (Kb) of the ASP with FSdsDNA has also been calculated both UV-Vis and DPV techniques.
作者简介
Mustafa Cesme
Faculty of Art and Sciences, Department of Chemistry
Email: aysgolcu@itu.edu.tr
土耳其, Kahramanmaras, 46040
Duygu Polat
Faculty of Art and Sciences, Department of Chemistry
Email: aysgolcu@itu.edu.tr
土耳其, Kahramanmaras, 46040
Pelin Senel
Faculty of Arts and Sciences, Department of Chemistry
Email: aysgolcu@itu.edu.tr
土耳其, Maslak, Istanbul, 34469
Aysegul Golcu
Faculty of Arts and Sciences, Department of Chemistry
编辑信件的主要联系方式.
Email: aysgolcu@itu.edu.tr
土耳其, Maslak, Istanbul, 34469
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