Development of a Glassy Carbon Electrode Modified with Graphene/Au Nanoparticles for Determination of Acetaminophen in Pharmaceutical Preparation

Abstract

A graphene/Au nanoparticles composite modified glassy carbon electrode (GR/AuNPs/GCE) was developed. Electrochemical behavior of acetaminophen (ACOP) at this modified electrode was studied by liner sweep voltammetry (LSV) in pH 6.0 phosphate buffer solution. The effect factors of the electrochemical response of ACOP were optimized by LSV. Under the optimum conditions, a linear calibration curve of the oxidation peak current of ACOP and concentration was obtained in the range of 1.0 × 10^–6 to ~2.2×10^–4 M. The peak current increases linearly with the scan rate, indicating that the reaction of ACOP at the modified electrode is adsorption-controlled process. This new proposed method has been successfully employed to determine acetaminophen in pharmaceutical preparation.