Sensitive Detection of Histamine at Metal-Organic Framework (Ni-BTC) Crystals and Multi-Walled Carbon Nanotubes Modified Glassy Carbon Electrode

Abstract

In this study a new electrochemical histamine sensor was proposed by using Ni-based metalorganic framework (Ni-BTC, BTC = 1,3,5-benzenetricarboxylate) crystals and multi-walled carbon nanotubes modified glassy carbon electrode. The modified electrode exhibited excellent electrocatalytic activity for the electro-oxidation of histamine with relatively high sensitivity and stability. The electro-oxidation of histamine was irreversible and exhibited an absorption-controlled behavior. A calibration curve for histamine in the concentration range from 1.00 to 160.00 μM with a detection limit of 0.41 μM (at signal to noise 3) and sensitivity of 0.19 μA μM^–1 was obtained. The suggested sensor was successfully used for quantitative determination of histamine in spiked human urine samples with satisfactory results.