A novel electrochemical biosensor for detection of cholesterol


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Аннотация

We report on a highly sensitive electrochemical biosensor for determination of cholesterol. The biosensor was fabricated by co-immobilizing bi-enzymes, cholesterol oxidase (ChOx), and horseradish peroxidase (HRP). Voltammetric technique such as cyclic voltammetry and impedance experiment were used to study the characterization of modified electrode step by step. The developed sensor is cheap, disposable, portable and exhibits higher sensitivity. The biosensor expressed a wide linear range up to 300 mg dL–1 in a physiological condition (pH 7.0), with a correlation coefficient of 0.9969. A sensitivity of 13.28 μA mg–1 dL cm−2 which makes it very promising for the clinical determination of cholesterol.

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Авторлар туралы

Lin Xu

State Key Laboratory of Materials-Oriented Chemical Engineering and College of Science; Nan Jing College of Chemical Technology

Email: iamqwu@njtech.edu.cn
ҚХР, 30 South Puzhu Road, Nanjing, 211816; 625 GeGuan Road, Nanjing, 210048

Yiting Hou

Key Laboratory for Organic Electronics & Information Displays (KLOEID)

Email: iamqwu@njtech.edu.cn
ҚХР, 9 Wenyuan Road, Yadong, Xincheng District, Nanjing, 210046

Mengdan Zhang

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM)

Email: iamqwu@njtech.edu.cn
ҚХР, 30 South Puzhu Road, Nanjing, 211816

Xin Yang

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM)

Email: iamqwu@njtech.edu.cn
ҚХР, 30 South Puzhu Road, Nanjing, 211816

Greath Jenkins

Key Laboratory for Organic Electronics & Information Displays (KLOEID)

Email: iamqwu@njtech.edu.cn
ҚХР, 9 Wenyuan Road, Yadong, Xincheng District, Nanjing, 210046

Wei Huang

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM)

Email: iamqwu@njtech.edu.cn
ҚХР, 30 South Puzhu Road, Nanjing, 211816

Cheng Yao

State Key Laboratory of Materials-Oriented Chemical Engineering and College of Science

Хат алмасуға жауапты Автор.
Email: yaocheng@njtech.edu.cn
ҚХР, 30 South Puzhu Road, Nanjing, 211816

Qiong Wu

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM)

Хат алмасуға жауапты Автор.
Email: iamqwu@njtech.edu.cn
ҚХР, 30 South Puzhu Road, Nanjing, 211816

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