MicroRNA Biogenesis Pathway Gene Polymorphisms Are Associated with Breast Cancer Risk
- 作者: Bermisheva M.1, Takhirova Z.1, Gilyazova I.1, Khusnutdinova E.1,2
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隶属关系:
- Institute of Biochemistry and Genetics, Ufa Science Center
- Department of Genetics and Fundamental Medicine
- 期: 卷 54, 编号 5 (2018)
- 页面: 568-575
- 栏目: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188980
- DOI: https://doi.org/10.1134/S1022795418040051
- ID: 188980
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详细
MicroRNAs (miRNAs) play an important role as epigenetic regulators in cancer initiation and progression. One of the mechanisms of miRNA dysregulation is altered functioning of proteins involved in miRNA processing machinery. It has been suggested that single nucleotide polymorphisms (SNPs) within miRNA gene regions, miRNA target genes, and miRNA machinery genes may affect the miRNAs regulation. We selected 25 SNPs in the key genes of miRNA biosynthesis, including DROSHA/RNASEN, DGCR8, DICER1, XPO5, RAN, PIWIL1/HIWI, AGO1/EIF2C1, AGO2, GEMIN4, GEMIN3/DDX20, and DDX5, and investigated the association between these SNPs and the risk of breast cancer. The total number of breast cancer cases and cancer-free controls enrolled in the investigation were 778 (417 breast cancer patients and 361 healthy women). We found that rs11060845 and rs10773771 in the PIWIL1 gene, rs3809142/RAN, rs10719/DROSHA, rs1640299/DGCR8, rs563002/DDX20, rs595055/AGO1, and rs2740348/GEMIN4 were associated with breast cancer risk in Russians.
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作者简介
M. Bermisheva
Institute of Biochemistry and Genetics, Ufa Science Center
编辑信件的主要联系方式.
Email: marina_berm@mail.ru
俄罗斯联邦, Ufa, 450054
Z. Takhirova
Institute of Biochemistry and Genetics, Ufa Science Center
Email: marina_berm@mail.ru
俄罗斯联邦, Ufa, 450054
I. Gilyazova
Institute of Biochemistry and Genetics, Ufa Science Center
Email: marina_berm@mail.ru
俄罗斯联邦, Ufa, 450054
E. Khusnutdinova
Institute of Biochemistry and Genetics, Ufa Science Center; Department of Genetics and Fundamental Medicine
Email: marina_berm@mail.ru
俄罗斯联邦, Ufa, 450054; Ufa, 450076