Ethnic Features of Genetic Susceptibility to Breast Cancer
- 作者: Bermisheva M.1, Bogdanova N.2, Gilyazova I.1, Zinnatullina G.3, Bisultanova Z.4, Khusnutdinova E.1,5
-
隶属关系:
- Institute of Biochemistry and Genetics
- Hannover Medical School
- Republican Clinical Oncology Center
- Department of Cell Biology, Morphology, and Microbiology
- Department of Genetics and Fundamental Medicine
- 期: 卷 54, 编号 2 (2018)
- 页面: 226-234
- 栏目: Medical Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188826
- DOI: https://doi.org/10.1134/S1022795418020047
- ID: 188826
如何引用文章
详细
The results of screening for BRCA1, BRCA2, ATM, NBN, CHEK2, PALB2, BLM gene mutations in 1000 breast cancer (BC) patients from the Republic of Bashkortostan (RB) are presented. Germline mutations in these genes accounted for 7.5% of breast cancer patients. The wide spectrum of mutations was found in women of Slavic origin, including: c.5266dupC, c.181T>G, and c.4034delA in BRCA1; c.5932G>T in ATM; c.657_661del5 in NBN; c.444+1G>A, c.1100delC, and dele9,10(5kb) in CHEK2; c.509_510delGA and c.172_175delTTGT in PALB2; and c.1642C>T in BLM gene.
作者简介
M. Bermisheva
Institute of Biochemistry and Genetics
编辑信件的主要联系方式.
Email: marina_berm@mail.ru
俄罗斯联邦, Ufa, 450054
N. Bogdanova
Hannover Medical School
Email: marina_berm@mail.ru
德国, Hannover, D-30625
I. Gilyazova
Institute of Biochemistry and Genetics
Email: marina_berm@mail.ru
俄罗斯联邦, Ufa, 450054
G. Zinnatullina
Republican Clinical Oncology Center
Email: marina_berm@mail.ru
俄罗斯联邦, Ufa, 450000
Z. Bisultanova
Department of Cell Biology, Morphology, and Microbiology
Email: marina_berm@mail.ru
俄罗斯联邦, Grozny, 364093
E. Khusnutdinova
Institute of Biochemistry and Genetics; Department of Genetics and Fundamental Medicine
Email: marina_berm@mail.ru
俄罗斯联邦, Ufa, 450054; Ufa, 450076