Molecular Genetic Studies of Cognitive Ability
- Autores: Malykh S.B.1,2, Malykh A.S.3,2, Karunas A.S.4, Enikeeva R.F.4, Davydova Y.D.4, Khusnutdinova E.K.4,2
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Afiliações:
- Psychological Institute, Russian Academy of Education
- Moscow State University
- National Research Nuclear University (Moscow Engineering Physics Institute)
- Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences
- Edição: Volume 55, Nº 7 (2019)
- Páginas: 783-793
- Seção: Reviews and Theoretical Articles
- URL: https://journals.rcsi.science/1022-7954/article/view/189432
- DOI: https://doi.org/10.1134/S1022795419070111
- ID: 189432
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Resumo
The paper presents a review of the results of molecular genetic studies of cognitive abilities. To date, a small number of genes responsible for normal cognitive functioning have been detected despite numerous studies based on the approach of candidate genes, genome-wide association studies, and linkage analyses. It should be considered that, even when the genetic variants were significantly associated with cognitive phenotypes, the sizes of the effect were usually very low (1–2%). However, large-scale genetic studies performed in the last few years significantly expanded the knowledge on the molecular basis of human cognitive abilities and made it possible to explain up to 20% of the 50% inheritance of intelligence.
Sobre autores
S. Malykh
Psychological Institute, Russian Academy of Education; Moscow State University
Autor responsável pela correspondência
Email: malykhsb@mail.ru
Rússia, Moscow, 125009; Moscow, 119991
A. Malykh
National Research Nuclear University (Moscow Engineering Physics Institute); Moscow State University
Email: carunas@list.ru
Rússia, Moscow, 115409; Moscow, 119991
A. Karunas
Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences
Autor responsável pela correspondência
Email: carunas@list.ru
Rússia, Ufa, 450054
R. Enikeeva
Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences
Email: carunas@list.ru
Rússia, Ufa, 450054
Y. Davydova
Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences
Email: carunas@list.ru
Rússia, Ufa, 450054
E. Khusnutdinova
Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences; Moscow State University
Email: carunas@list.ru
Rússia, Ufa, 450054; Moscow, 119991
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