An Analysis of the Associations of Polymorphic Variants of the LEPR (rs1137100), LRP5 (rs3736228), and LPL (rs320) Genes with the Risk of Developing Type 2 Diabetes Mellitus
- Авторы: Kochetova O.1, Avzaletdinova D.2, Sharipova L.2, Korytina G.1, Akhmadishina L.1, Morugova T.2, Mustafina O.1
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Учреждения:
- Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
- Bashkortostan State Medical University
- Выпуск: Том 55, № 4 (2019)
- Страницы: 495-503
- Раздел: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/189336
- DOI: https://doi.org/10.1134/S1022795419040057
- ID: 189336
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Аннотация
Diabetes mellitus is a hereditary predisposed multifactorial disease. However, the genetic mechanisms of its development have not been fully revealed yet. We conducted a search for associations of polymorphic variants of the LEPR (rs1137100), LRP5 (rs3736228), and LPL (rs320) genes involved in the development of obesity with the development of type 2 diabetes mellitus. The association with development of the disease was established for the T allele of the LRP5 locus (rs3736228) (p = 0.029, OR = 1.46). The rs1137100 locus (p = 0.032) of the LEPR gene was shown to be associated with the body mass index (BMI), but it was not connected with the presence of type 2 diabetes mellitus. Risk markers of development of type 2 diabetes included the T allele of the rs3736228 locus of the LRP5 gene (OR = 1.74, p = 0.012) and the G allele of the rs320 locus of the LPL gene (OR = 1.39, p = 0.027). Statistically significant association was only found in the group of nonobese patients. A decrease in the level of low-density lipoprotein was observed in individuals with the TT genotype of the LPL locus (rs320) (p = 0.04). Individuals with the GT and GG genotypes of this locus had a lower cholesterol level (p = 0.027). A decrease in the level of BMI (p = 0.012) and a decrease in the concentration of triglycerides in the blood (p = 0.00000004) were detected in carriers of the CC genotype of the LRP5 rs3736228 locus.
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O. Kochetova
Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: Olga_mk78@mail.ru
Россия, Ufa, 450054
D. Avzaletdinova
Bashkortostan State Medical University
Email: Olga_mk78@mail.ru
Россия, Ufa, 450000
L. Sharipova
Bashkortostan State Medical University
Email: Olga_mk78@mail.ru
Россия, Ufa, 450000
G. Korytina
Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
Email: Olga_mk78@mail.ru
Россия, Ufa, 450054
L. Akhmadishina
Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
Email: Olga_mk78@mail.ru
Россия, Ufa, 450054
T. Morugova
Bashkortostan State Medical University
Email: Olga_mk78@mail.ru
Россия, Ufa, 450000
O. Mustafina
Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
Email: Olga_mk78@mail.ru
Россия, Ufa, 450054