An Analysis of the Associations of Polymorphic Variants of the LEPR (rs1137100), LRP5 (rs3736228), and LPL (rs320) Genes with the Risk of Developing Type 2 Diabetes Mellitus
- Authors: Kochetova O.V.1, Avzaletdinova D.S.2, Sharipova L.F.2, Korytina G.F.1, Akhmadishina L.Z.1, Morugova T.V.2, Mustafina O.E.1
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Affiliations:
- Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
- Bashkortostan State Medical University
- Issue: Vol 55, No 4 (2019)
- Pages: 495-503
- Section: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/189336
- DOI: https://doi.org/10.1134/S1022795419040057
- ID: 189336
Cite item
Abstract
Diabetes mellitus is a hereditary predisposed multifactorial disease. However, the genetic mechanisms of its development have not been fully revealed yet. We conducted a search for associations of polymorphic variants of the LEPR (rs1137100), LRP5 (rs3736228), and LPL (rs320) genes involved in the development of obesity with the development of type 2 diabetes mellitus. The association with development of the disease was established for the T allele of the LRP5 locus (rs3736228) (p = 0.029, OR = 1.46). The rs1137100 locus (p = 0.032) of the LEPR gene was shown to be associated with the body mass index (BMI), but it was not connected with the presence of type 2 diabetes mellitus. Risk markers of development of type 2 diabetes included the T allele of the rs3736228 locus of the LRP5 gene (OR = 1.74, p = 0.012) and the G allele of the rs320 locus of the LPL gene (OR = 1.39, p = 0.027). Statistically significant association was only found in the group of nonobese patients. A decrease in the level of low-density lipoprotein was observed in individuals with the TT genotype of the LPL locus (rs320) (p = 0.04). Individuals with the GT and GG genotypes of this locus had a lower cholesterol level (p = 0.027). A decrease in the level of BMI (p = 0.012) and a decrease in the concentration of triglycerides in the blood (p = 0.00000004) were detected in carriers of the CC genotype of the LRP5 rs3736228 locus.
About the authors
O. V. Kochetova
Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
Author for correspondence.
Email: Olga_mk78@mail.ru
Russian Federation, Ufa, 450054
D. S. Avzaletdinova
Bashkortostan State Medical University
Email: Olga_mk78@mail.ru
Russian Federation, Ufa, 450000
L. F. Sharipova
Bashkortostan State Medical University
Email: Olga_mk78@mail.ru
Russian Federation, Ufa, 450000
G. F. Korytina
Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
Email: Olga_mk78@mail.ru
Russian Federation, Ufa, 450054
L. Z. Akhmadishina
Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
Email: Olga_mk78@mail.ru
Russian Federation, Ufa, 450054
T. V. Morugova
Bashkortostan State Medical University
Email: Olga_mk78@mail.ru
Russian Federation, Ufa, 450000
O. E. Mustafina
Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
Email: Olga_mk78@mail.ru
Russian Federation, Ufa, 450054