电邮这篇文章 Role of Gene-Gene Interactions in the Chromosomal Instability in Workers at Coal Thermal Power Plants
- 作者: Savchenko Y.A.1, Minina V.I.1,2, Bakanova M.L.1, Ryzhkova A.V.1, Soboleva O.A.1, Kulemin Y.E.1,2, Voronina E.N.3, Glushkov A.N.1,2, Vafin I.A.4
-
隶属关系:
- Federal Research Center of Coal and Coal Chemistry, Siberian Branch
- Chair of Genetics
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
- Kemerovo Regional Blood Center
- 期: 卷 54, 编号 1 (2018)
- 页面: 91-102
- 栏目: Medical Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188780
- DOI: https://doi.org/10.1134/S1022795418010106
- ID: 188780
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
订阅存取
详细
The 23 polymorphic variants in genes encoding the enzymes of xenobiotics biotransformation (CYP1A1 (rs4646903), CYP1A2 (rs762551), GSTP1 (rs1138272, rs1695), GSTM1 (del), and GSTT1 (del)), DNA repair (XRCC1 (rs25489, rs25487), APEX1 (rs1130409), hOGG1 (rs1052133), ADPRT (rs1136410), XPD (rs13181), XPG (rs17655), XPC (rs2228001), ATM (rs1801516), NBS (rs1805794), XRCC2 (rs3218536), and XRCC3 (rs861539)), antioxidant system (MnSOD (rs4880) and GPx1 (rs1050450)), cell cycle control and apoptosis (TP53 (rs1042522)), DNA methylation (MTHFR (rs1801133) and MTR (rs1805087)), and chromosomal aberrations in lymphocytes in the workers at thermal power plants were analyzed. We found that allelic variants in the CYP1A1 (rs4646903), hOGG1 (rs1052133), XRCC1 (rs25487), and APEX1 (rs1130409) genes were associated with an increased level of chromosomal aberrations in workers. Informative models of gene-gene interactions including CYP1A1 (rs4646903, T>C), CYP1A2 (rs762551, C>A), GSTT1 (del); XRCC1 (rs25487, G>A), MTHFR (rs1801133, C>T), GSTT1 (del); XRCC1 (rs25487, G>A), APEX1 (rs1130409, T>G), TP53 (rs1042522, G>C) determining the formation of the increased frequency of chromosomal aberrations in the workers at coal thermal power plants were discovered.
作者简介
Ya. Savchenko
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
编辑信件的主要联系方式.
Email: yasavchenko@ya.ru
俄罗斯联邦, Kemerovo, 650099
V. Minina
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Chair of Genetics
Email: yasavchenko@ya.ru
俄罗斯联邦, Kemerovo, 650099; Kemerovo, 650000
M. Bakanova
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: yasavchenko@ya.ru
俄罗斯联邦, Kemerovo, 650099
A. Ryzhkova
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: yasavchenko@ya.ru
俄罗斯联邦, Kemerovo, 650099
O. Soboleva
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: yasavchenko@ya.ru
俄罗斯联邦, Kemerovo, 650099
Yu. Kulemin
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Chair of Genetics
Email: yasavchenko@ya.ru
俄罗斯联邦, Kemerovo, 650099; Kemerovo, 650000
E. Voronina
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: yasavchenko@ya.ru
俄罗斯联邦, Novosibirsk, 630090
A. Glushkov
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Chair of Genetics
Email: yasavchenko@ya.ru
俄罗斯联邦, Kemerovo, 650099; Kemerovo, 650000
I. Vafin
Kemerovo Regional Blood Center
Email: yasavchenko@ya.ru
俄罗斯联邦, Kemerovo, 650000
补充文件
