Отправить статью по E-mail Role of Gene-Gene Interactions in the Chromosomal Instability in Workers at Coal Thermal Power Plants
- Авторы: Savchenko Y.A.1, Minina V.I.1,2, Bakanova M.L.1, Ryzhkova A.V.1, Soboleva O.A.1, Kulemin Y.E.1,2, Voronina E.N.3, Glushkov A.N.1,2, Vafin I.A.4
-
Учреждения:
- Federal Research Center of Coal and Coal Chemistry, Siberian Branch
- Chair of Genetics
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
- Kemerovo Regional Blood Center
- Выпуск: Том 54, № 1 (2018)
- Страницы: 91-102
- Раздел: Medical Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188780
- DOI: https://doi.org/10.1134/S1022795418010106
- ID: 188780
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
The 23 polymorphic variants in genes encoding the enzymes of xenobiotics biotransformation (CYP1A1 (rs4646903), CYP1A2 (rs762551), GSTP1 (rs1138272, rs1695), GSTM1 (del), and GSTT1 (del)), DNA repair (XRCC1 (rs25489, rs25487), APEX1 (rs1130409), hOGG1 (rs1052133), ADPRT (rs1136410), XPD (rs13181), XPG (rs17655), XPC (rs2228001), ATM (rs1801516), NBS (rs1805794), XRCC2 (rs3218536), and XRCC3 (rs861539)), antioxidant system (MnSOD (rs4880) and GPx1 (rs1050450)), cell cycle control and apoptosis (TP53 (rs1042522)), DNA methylation (MTHFR (rs1801133) and MTR (rs1805087)), and chromosomal aberrations in lymphocytes in the workers at thermal power plants were analyzed. We found that allelic variants in the CYP1A1 (rs4646903), hOGG1 (rs1052133), XRCC1 (rs25487), and APEX1 (rs1130409) genes were associated with an increased level of chromosomal aberrations in workers. Informative models of gene-gene interactions including CYP1A1 (rs4646903, T>C), CYP1A2 (rs762551, C>A), GSTT1 (del); XRCC1 (rs25487, G>A), MTHFR (rs1801133, C>T), GSTT1 (del); XRCC1 (rs25487, G>A), APEX1 (rs1130409, T>G), TP53 (rs1042522, G>C) determining the formation of the increased frequency of chromosomal aberrations in the workers at coal thermal power plants were discovered.
Об авторах
Ya. Savchenko
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Автор, ответственный за переписку.
Email: yasavchenko@ya.ru
Россия, Kemerovo, 650099
V. Minina
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Chair of Genetics
Email: yasavchenko@ya.ru
Россия, Kemerovo, 650099; Kemerovo, 650000
M. Bakanova
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: yasavchenko@ya.ru
Россия, Kemerovo, 650099
A. Ryzhkova
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: yasavchenko@ya.ru
Россия, Kemerovo, 650099
O. Soboleva
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: yasavchenko@ya.ru
Россия, Kemerovo, 650099
Yu. Kulemin
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Chair of Genetics
Email: yasavchenko@ya.ru
Россия, Kemerovo, 650099; Kemerovo, 650000
E. Voronina
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: yasavchenko@ya.ru
Россия, Novosibirsk, 630090
A. Glushkov
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Chair of Genetics
Email: yasavchenko@ya.ru
Россия, Kemerovo, 650099; Kemerovo, 650000
I. Vafin
Kemerovo Regional Blood Center
Email: yasavchenko@ya.ru
Россия, Kemerovo, 650000
Дополнительные файлы
