Отправить статью по E-mail The heteroplasmy level of some mutations in gene MT-CYB among women with asymptomatic atherosclerosis
- Авторы: Sinyov V.V.1, Chicheva M.M.2, Barinova V.A.1, Ryzhkova A.I.2,3, Zilinyi R.I.4, Karagodin V.P.5, Postnov A.Y.1, Sobenin I.A.1,2, Orekhov A.N.2,3,6, Sazonova M.A.1,2
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Учреждения:
- Russian Cardiology Research and Production Complex
- Research Institute of General Pathology and Pathophysiology
- Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
- University of Debrecen Medical and Health Science Centre
- Plekhanov Russian University of Economics
- Institute for Atherosclerosis Research
- Выпуск: Том 52, № 8 (2016)
- Страницы: 847-852
- Раздел: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/187840
- DOI: https://doi.org/10.1134/S1022795416080123
- ID: 187840
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Аннотация
Atherosclerosis is a polygenic socially significant disease whose risk factors include coronary heart disease, diabetes, hypertension, and myocardial infarction. According to the literature, mutations m.14846G>A (G34S), m.15762G>A (G339Q), m.15084G>A (W113Ter), and m.15059G>A (G190Ter) of cytochrome B gene (MT-CYB) are associated with mitochondrial myopathies, myoglobinuria, and exercise intolerance. Preliminary studies carried out by the authors made it possible to discover an association of certain mitochondrial genome mutations with atherosclerotic lesions of aortic intima in people who died as a result of an accident or sudden death. The most interesting seemed to be the data on the association of mutations m.14846G>A and m.15059G>A of the cytochrome B gene with lipofibrous aortic plaques, because these mutations affect the mitochondrial respiratory chain enzyme. Defects in the given chain may be the reason for the launch of pathogenic mechanisms in the human body. Owing to the fact that mutations in the mitochondrial genome are inherited by the maternal type, it was decided to analyze cytochrome B gene mutations in a sample of female volunteers from Moscow oblast. According to the findings, mutations m.14846G>A and m.15059G>A are highly significantly associated with atherosclerotic lesions of the carotid arteries: m.14846G>A is antiatherogenic and m.15059G>A is proatherogenic.
Об авторах
V. Sinyov
Russian Cardiology Research and Production Complex
Автор, ответственный за переписку.
Email: centaureaceanus@mail.ru
Россия, Moscow, 121552
M. Chicheva
Research Institute of General Pathology and Pathophysiology
Email: centaureaceanus@mail.ru
Россия, Moscow, 125315
V. Barinova
Russian Cardiology Research and Production Complex
Email: centaureaceanus@mail.ru
Россия, Moscow, 121552
A. Ryzhkova
Research Institute of General Pathology and Pathophysiology; Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: centaureaceanus@mail.ru
Россия, Moscow, 125315; Moscow, 109472
R. Zilinyi
University of Debrecen Medical and Health Science Centre
Email: centaureaceanus@mail.ru
Венгрия, Debrecen, 4012
V. Karagodin
Plekhanov Russian University of Economics
Email: centaureaceanus@mail.ru
Россия, Moscow, 117997
A. Postnov
Russian Cardiology Research and Production Complex
Email: centaureaceanus@mail.ru
Россия, Moscow, 121552
I. Sobenin
Russian Cardiology Research and Production Complex; Research Institute of General Pathology and Pathophysiology
Email: centaureaceanus@mail.ru
Россия, Moscow, 121552; Moscow, 125315
A. Orekhov
Research Institute of General Pathology and Pathophysiology; Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology; Institute for Atherosclerosis Research
Email: centaureaceanus@mail.ru
Россия, Moscow, 125315; Moscow, 109472; Moscow oblast, Skolkovo, 121609
M. Sazonova
Russian Cardiology Research and Production Complex; Research Institute of General Pathology and Pathophysiology
Email: centaureaceanus@mail.ru
Россия, Moscow, 121552; Moscow, 125315
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