Мақаланы E-mail арқылы жіберу The heteroplasmy level of some mutations in gene MT-CYB among women with asymptomatic atherosclerosis
- Авторлар: Sinyov V.V.1, Chicheva M.M.2, Barinova V.A.1, Ryzhkova A.I.2,3, Zilinyi R.I.4, Karagodin V.P.5, Postnov A.Y.1, Sobenin I.A.1,2, Orekhov A.N.2,3,6, Sazonova M.A.1,2
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Мекемелер:
- Russian Cardiology Research and Production Complex
- Research Institute of General Pathology and Pathophysiology
- Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
- University of Debrecen Medical and Health Science Centre
- Plekhanov Russian University of Economics
- Institute for Atherosclerosis Research
- Шығарылым: Том 52, № 8 (2016)
- Беттер: 847-852
- Бөлім: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/187840
- DOI: https://doi.org/10.1134/S1022795416080123
- ID: 187840
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Atherosclerosis is a polygenic socially significant disease whose risk factors include coronary heart disease, diabetes, hypertension, and myocardial infarction. According to the literature, mutations m.14846G>A (G34S), m.15762G>A (G339Q), m.15084G>A (W113Ter), and m.15059G>A (G190Ter) of cytochrome B gene (MT-CYB) are associated with mitochondrial myopathies, myoglobinuria, and exercise intolerance. Preliminary studies carried out by the authors made it possible to discover an association of certain mitochondrial genome mutations with atherosclerotic lesions of aortic intima in people who died as a result of an accident or sudden death. The most interesting seemed to be the data on the association of mutations m.14846G>A and m.15059G>A of the cytochrome B gene with lipofibrous aortic plaques, because these mutations affect the mitochondrial respiratory chain enzyme. Defects in the given chain may be the reason for the launch of pathogenic mechanisms in the human body. Owing to the fact that mutations in the mitochondrial genome are inherited by the maternal type, it was decided to analyze cytochrome B gene mutations in a sample of female volunteers from Moscow oblast. According to the findings, mutations m.14846G>A and m.15059G>A are highly significantly associated with atherosclerotic lesions of the carotid arteries: m.14846G>A is antiatherogenic and m.15059G>A is proatherogenic.
Авторлар туралы
V. Sinyov
Russian Cardiology Research and Production Complex
Хат алмасуға жауапты Автор.
Email: centaureaceanus@mail.ru
Ресей, Moscow, 121552
M. Chicheva
Research Institute of General Pathology and Pathophysiology
Email: centaureaceanus@mail.ru
Ресей, Moscow, 125315
V. Barinova
Russian Cardiology Research and Production Complex
Email: centaureaceanus@mail.ru
Ресей, Moscow, 121552
A. Ryzhkova
Research Institute of General Pathology and Pathophysiology; Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: centaureaceanus@mail.ru
Ресей, Moscow, 125315; Moscow, 109472
R. Zilinyi
University of Debrecen Medical and Health Science Centre
Email: centaureaceanus@mail.ru
Венгрия, Debrecen, 4012
V. Karagodin
Plekhanov Russian University of Economics
Email: centaureaceanus@mail.ru
Ресей, Moscow, 117997
A. Postnov
Russian Cardiology Research and Production Complex
Email: centaureaceanus@mail.ru
Ресей, Moscow, 121552
I. Sobenin
Russian Cardiology Research and Production Complex; Research Institute of General Pathology and Pathophysiology
Email: centaureaceanus@mail.ru
Ресей, Moscow, 121552; Moscow, 125315
A. Orekhov
Research Institute of General Pathology and Pathophysiology; Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology; Institute for Atherosclerosis Research
Email: centaureaceanus@mail.ru
Ресей, Moscow, 125315; Moscow, 109472; Moscow oblast, Skolkovo, 121609
M. Sazonova
Russian Cardiology Research and Production Complex; Research Institute of General Pathology and Pathophysiology
Email: centaureaceanus@mail.ru
Ресей, Moscow, 121552; Moscow, 125315
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