SWI/SNF protein complexes participate in the initiation and elongation stages of Drosophila hsp70 gene transcription
- Авторы: Mazina M.1, Nikolenko Y.1, Krasnov A.1, Vorobyeva N.1
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Учреждения:
- Institute of Gene Biology
- Выпуск: Том 52, № 2 (2016)
- Страницы: 141-145
- Раздел: Molecular Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/187640
- DOI: https://doi.org/10.1134/S1022795416010105
- ID: 187640
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Аннотация
The participation of the SWI/SNF chromatin remodeling complex in the stimulation of the RNA polymerase II binding to gene promotors was demonstrated in all model eukaryotic organisms. It was shown eight years ago that the SWI/SNF complex influence on transcription is not limited to its role in initiation but also includes participation in elongation and alternative splicing. In the current work, we describe the subunit composition of the SWI/SNF complexes participating in initiation, preparing for the elongation and elongation of hsp70 gene transcription in Drosophila melanogaster. The data reveal the high mobility of the SWI/SNF complex composition during the hsp70 gene transcription process. We suggest a model describing the process of sequential SWI/SNF complex formation during heat-shock induced transcription of the hsp70 gene.
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Об авторах
M. Mazina
Institute of Gene Biology
Автор, ответственный за переписку.
Email: info@genebiology.ru
Россия, Moscow, 119334
Yu. Nikolenko
Institute of Gene Biology
Email: info@genebiology.ru
Россия, Moscow, 119334
A. Krasnov
Institute of Gene Biology
Email: info@genebiology.ru
Россия, Moscow, 119334
N. Vorobyeva
Institute of Gene Biology
Email: info@genebiology.ru
Россия, Moscow, 119334