Heterogeneity in Colorectal Primary Tumor and Synchronous Liver Metastases


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The expression profile of the ZEB1, ZEB2, VIM, CDH1, SFRP2, FOXQ1, TNC, MACC1, PLS3, CFTR, FLNA, MUC2, TFF3, and RARRES3 genes, as well as the mutational status of the KRAS, NRAS, BRAF, and PIK3CA genes, were investigated in 40 patients with colorectal cancer and liver metastases. A comparative analysis of changes in gene expression in primary tumor cells and liver metastases was performed. Statistically significant differences were found between the expression levels of the ZEB2 (p = 0.004), VIM (p < 0.001), FLNA (p = 0.04), and MUC2 (p < 0.001) genes. It was demonstrated that the overall frequency of mutations of the KRAS gene was 18/40 (45%) and the PIK3CA gene was 9/40 (23%). Mutations in the NRAS and BRAF genes were not found. The concordance between the primary tumor and metastases in the liver by mutation status was 100%.

Sobre autores

V. Shubin

State Scientific Centre of Coloproctology

Autor responsável pela correspondência
Email: shwit@mail.ru
Rússia, Moscow, 123423

A. Ponomarenko

State Scientific Centre of Coloproctology

Email: shwit@mail.ru
Rússia, Moscow, 123423

A. Tsukanov

State Scientific Centre of Coloproctology

Email: shwit@mail.ru
Rússia, Moscow, 123423

O. Maynovskaya

State Scientific Centre of Coloproctology

Email: shwit@mail.ru
Rússia, Moscow, 123423

E. Rybakov

State Scientific Centre of Coloproctology

Email: shwit@mail.ru
Rússia, Moscow, 123423

M. Panina

State Scientific Centre of Coloproctology

Email: shwit@mail.ru
Rússia, Moscow, 123423

V. Kashnikov

State Scientific Centre of Coloproctology

Email: shwit@mail.ru
Rússia, Moscow, 123423

S. Frolov

State Scientific Centre of Coloproctology

Email: shwit@mail.ru
Rússia, Moscow, 123423

Yu. Shelygin

State Scientific Centre of Coloproctology

Email: shwit@mail.ru
Rússia, Moscow, 123423

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