Heterogeneity in Colorectal Primary Tumor and Synchronous Liver Metastases
- Autores: Shubin V.P.1, Ponomarenko A.A.1, Tsukanov A.S.1, Maynovskaya O.A.1, Rybakov E.G.1, Panina M.V.1, Kashnikov V.N.1, Frolov S.A.1, Shelygin Y.A.1
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Afiliações:
- State Scientific Centre of Coloproctology
- Edição: Volume 54, Nº 6 (2018)
- Páginas: 698-702
- Seção: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/189020
- DOI: https://doi.org/10.1134/S1022795418060091
- ID: 189020
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Resumo
The expression profile of the ZEB1, ZEB2, VIM, CDH1, SFRP2, FOXQ1, TNC, MACC1, PLS3, CFTR, FLNA, MUC2, TFF3, and RARRES3 genes, as well as the mutational status of the KRAS, NRAS, BRAF, and PIK3CA genes, were investigated in 40 patients with colorectal cancer and liver metastases. A comparative analysis of changes in gene expression in primary tumor cells and liver metastases was performed. Statistically significant differences were found between the expression levels of the ZEB2 (p = 0.004), VIM (p < 0.001), FLNA (p = 0.04), and MUC2 (p < 0.001) genes. It was demonstrated that the overall frequency of mutations of the KRAS gene was 18/40 (45%) and the PIK3CA gene was 9/40 (23%). Mutations in the NRAS and BRAF genes were not found. The concordance between the primary tumor and metastases in the liver by mutation status was 100%.
Sobre autores
V. Shubin
State Scientific Centre of Coloproctology
Autor responsável pela correspondência
Email: shwit@mail.ru
Rússia, Moscow, 123423
A. Ponomarenko
State Scientific Centre of Coloproctology
Email: shwit@mail.ru
Rússia, Moscow, 123423
A. Tsukanov
State Scientific Centre of Coloproctology
Email: shwit@mail.ru
Rússia, Moscow, 123423
O. Maynovskaya
State Scientific Centre of Coloproctology
Email: shwit@mail.ru
Rússia, Moscow, 123423
E. Rybakov
State Scientific Centre of Coloproctology
Email: shwit@mail.ru
Rússia, Moscow, 123423
M. Panina
State Scientific Centre of Coloproctology
Email: shwit@mail.ru
Rússia, Moscow, 123423
V. Kashnikov
State Scientific Centre of Coloproctology
Email: shwit@mail.ru
Rússia, Moscow, 123423
S. Frolov
State Scientific Centre of Coloproctology
Email: shwit@mail.ru
Rússia, Moscow, 123423
Yu. Shelygin
State Scientific Centre of Coloproctology
Email: shwit@mail.ru
Rússia, Moscow, 123423
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