MicroRNA Biogenesis Pathway Gene Polymorphisms Are Associated with Breast Cancer Risk
- Autores: Bermisheva M.1, Takhirova Z.1, Gilyazova I.1, Khusnutdinova E.1,2
-
Afiliações:
- Institute of Biochemistry and Genetics, Ufa Science Center
- Department of Genetics and Fundamental Medicine
- Edição: Volume 54, Nº 5 (2018)
- Páginas: 568-575
- Seção: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188980
- DOI: https://doi.org/10.1134/S1022795418040051
- ID: 188980
Citar
Resumo
MicroRNAs (miRNAs) play an important role as epigenetic regulators in cancer initiation and progression. One of the mechanisms of miRNA dysregulation is altered functioning of proteins involved in miRNA processing machinery. It has been suggested that single nucleotide polymorphisms (SNPs) within miRNA gene regions, miRNA target genes, and miRNA machinery genes may affect the miRNAs regulation. We selected 25 SNPs in the key genes of miRNA biosynthesis, including DROSHA/RNASEN, DGCR8, DICER1, XPO5, RAN, PIWIL1/HIWI, AGO1/EIF2C1, AGO2, GEMIN4, GEMIN3/DDX20, and DDX5, and investigated the association between these SNPs and the risk of breast cancer. The total number of breast cancer cases and cancer-free controls enrolled in the investigation were 778 (417 breast cancer patients and 361 healthy women). We found that rs11060845 and rs10773771 in the PIWIL1 gene, rs3809142/RAN, rs10719/DROSHA, rs1640299/DGCR8, rs563002/DDX20, rs595055/AGO1, and rs2740348/GEMIN4 were associated with breast cancer risk in Russians.
Palavras-chave
Sobre autores
M. Bermisheva
Institute of Biochemistry and Genetics, Ufa Science Center
Autor responsável pela correspondência
Email: marina_berm@mail.ru
Rússia, Ufa, 450054
Z. Takhirova
Institute of Biochemistry and Genetics, Ufa Science Center
Email: marina_berm@mail.ru
Rússia, Ufa, 450054
I. Gilyazova
Institute of Biochemistry and Genetics, Ufa Science Center
Email: marina_berm@mail.ru
Rússia, Ufa, 450054
E. Khusnutdinova
Institute of Biochemistry and Genetics, Ufa Science Center; Department of Genetics and Fundamental Medicine
Email: marina_berm@mail.ru
Rússia, Ufa, 450054; Ufa, 450076