Search for genetic markers of climatic adaptation in populations of North Eurasia


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Genetic diversity of native populations of North Eurasia is investigated using a panel of genetic markers of candidate genes for cold climate adaptation. A high level of within- and between-population variability is detected. Comparative analysis of data on North Eurasian populations combined with data on worldwide populations from the 1000 Genomes and HDGP projects reveals correlations of genetic diversity in candidate genes for cold climate adaptation with key climate parameters, as well as the increase of genetic diversity in markers of this group of genes with the increase of latitude, that is, as modern humans migrated out of Africa. Using the method of searching for extreme empirical values of the coefficient of genetic diversity, signals of directional selection for markers of six genes adaptive to cold (MYOF, LONP2, IFNL4, MKL1, SLC2A12, and CPT1A) are found. The data are discussed in framework of the hypothesis of decanalization of genome–phenome relationships under the pressure of natural selection during human settlement throughout the world.

Авторлар туралы

V. Stepanov

Institute of Medical Genetics; Department of Cytology and Genetics

Хат алмасуға жауапты Автор.
Email: vadim.stepanov@medgenetics.ru
Ресей, Tomsk, 634050; Tomsk, 634050

V. Kharkov

Institute of Medical Genetics; Department of Cytology and Genetics

Email: vadim.stepanov@medgenetics.ru
Ресей, Tomsk, 634050; Tomsk, 634050

K. Vagaitseva

Institute of Medical Genetics; Department of Cytology and Genetics

Email: vadim.stepanov@medgenetics.ru
Ресей, Tomsk, 634050; Tomsk, 634050

A. Bocharova

Institute of Medical Genetics

Email: vadim.stepanov@medgenetics.ru
Ресей, Tomsk, 634050

A. Kazantsev

Tomsk Polytechnic University

Email: vadim.stepanov@medgenetics.ru
Ресей, Tomsk, 634050

A. Popovich

Institute of Medical Genetics

Email: vadim.stepanov@medgenetics.ru
Ресей, Tomsk, 634050

I. Khitrinskaya

Institute of Medical Genetics

Email: vadim.stepanov@medgenetics.ru
Ресей, Tomsk, 634050

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

© Pleiades Publishing, Inc., 2017