Molecular Genetic Study of Association of the MTRR Gene A66G SNP with Dental Caries in Children with Congenital Cleft Lip and/or Palate and without Pathology
- Autores: Udina I.G.1, Uchaeva V.S.1, Volobuyev V.V.2, Gracheva A.S.1, Vasiliev Y.A.2
-
Afiliações:
- Vavilov Institute of General Genetics, Russian Academy of Sciences
- Kuban State Medical University
- Edição: Volume 55, Nº 12 (2019)
- Páginas: 1577-1581
- Seção: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/189909
- DOI: https://doi.org/10.1134/S1022795419120111
- ID: 189909
Citar
Resumo
Association of the A66G SNP in the MTRR gene with dental caries was studied in children with congenital anomalies of the maxillofacial region (CA of MFR), i.e., with congenital cleft lip with or without cleft palate (CL, CP, and CLP) and in children without congenital anomalies. Comparison of samples of children with CL, CP, and CLP and children without congenital anomalies revealed association of the A66G SNP of the MTRR gene with the considered anomalies, which made it impossible to establish probable association of this marker with caries (for the G/G genotype, an association with the increased risk for developing CA of MFR was observed: OR = 2.16; P = 0.046; 95% CI (1.00–4.67). In children without pathology, an association of the A66G SNP of the MTRR gene with early caries was revealed. In carriers of the A/A genotype among children with primary and mixed bite (N = 91) and the mean age of 6.51 ± 0.2 years, the risk for developing more severe form of caries was higher: OR = 4.91; P = 0.006; 95% CI (1.53–15.78); and among children with primary bite (N = 53) and the mean age of 4.71 ± 0.18 years, OR = 10.53; P = 0.024; 95% CI (1.19–485.29). In children with heterozygous A/G genotype, the resistance to more severe form of caries was observed. Therefore, the A66G SNP of the MTRR gene can be considered as a marker of early caries in children without congenital anomalies.
Palavras-chave
Sobre autores
I. Udina
Vavilov Institute of General Genetics, Russian Academy of Sciences
Autor responsável pela correspondência
Email: irina_udina@mail.ru
Rússia, Moscow, 119991
V. Uchaeva
Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: irina_udina@mail.ru
Rússia, Moscow, 119991
V. Volobuyev
Kuban State Medical University
Email: irina_udina@mail.ru
Rússia, Krasnodar, 350063
A. Gracheva
Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: irina_udina@mail.ru
Rússia, Moscow, 119991
Yu. Vasiliev
Kuban State Medical University
Email: irina_udina@mail.ru
Rússia, Krasnodar, 350063
Arquivos suplementares
